{"id":2340,"date":"2020-10-01T16:35:17","date_gmt":"2020-10-01T13:35:17","guid":{"rendered":"https:\/\/www.intheranostics.com\/?page_id=2340"},"modified":"2021-02-22T15:54:15","modified_gmt":"2021-02-22T12:54:15","slug":"lutetium-177-dota-tate","status":"publish","type":"page","link":"https:\/\/www.intheranostics.com\/en\/lutetium-177-dota-tate\/","title":{"rendered":"Lutetium-177 DOTA-TATE"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.4.8&#8243; background_color=&#8221;rgba(0,0,0,0)&#8221; background_image=&#8221;https:\/\/www.intheranostics.com\/wp-content\/uploads\/2020\/06\/metastatik_prostat_kanseri.jpg&#8221; custom_padding=&#8221;100px||100px||false|false&#8221; locked=&#8221;off&#8221;][et_pb_fullwidth_header title=&#8221;Lutetium-177 DOTA-TATE&#8221; text_orientation=&#8221;center&#8221; content_max_width_last_edited=&#8221;off|desktop&#8221; _builder_version=&#8221;4.4.8&#8243; title_font_size=&#8221;50px&#8221; content_font_size=&#8221;41px&#8221; subhead_font=&#8221;|700|||||||&#8221; subhead_font_size=&#8221;38px&#8221; subhead_line_height=&#8221;1.1em&#8221; background_enable_color=&#8221;off&#8221; background_enable_image=&#8221;off&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221;][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.4.8&#8243; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221;][et_pb_row _builder_version=&#8221;4.4.8&#8243; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.4.8&#8243;][et_pb_divider divider_weight=&#8221;0px&#8221; _builder_version=&#8221;4.4.8&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_start=&#8221;#8dd2e1&#8243; background_color_gradient_end=&#8221;#23afca&#8221; background_color_gradient_direction=&#8221;90deg&#8221; width=&#8221;50%&#8221; module_alignment=&#8221;center&#8221; height=&#8221;10px&#8221;][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; _builder_version=&#8221;4.4.8&#8243;][et_pb_row admin_label=&#8221;row&#8221; _builder_version=&#8221;4.4.8&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.4.8&#8243; hover_enabled=&#8221;0&#8243;]<\/p>\n<h2>What is Lutetium-177 DOTA-TATE Therapy ?<\/h2>\n<p><strong>\u00a0<\/strong>Neuroendocrine tumors (NET); They are rare cancers that can occur anywhere in the body, especially in the intestine, pancreas and lungs.<\/p>\n<p>Theranostic is a new and emerging field in the medical world. It is based on the realization of imaging and treatment on a single system, allowing the specific treatment and follow-up of treatment simultaneously.<\/p>\n<p>Diagnosis and treatment of neuroendocrine tumors can be done by using some imaging agents in theranostic applications. Of these agents, Ga-68 DOTA-TATE PET \/ CT can visualize tumoral tissues with high sensitivity, and Lu-177 DOTA-TATE can perform specific and targeted treatment of tumoral tissues. This is a very successful and new method for theranostic applications.<\/p>\n<p>Lu-177 DOTA-TATE is a treatment method used in neuroendocrine tumors. It is also referred to by different names such as &#8220;targeted radionuclide therapy&#8221;, &#8220;peptide receptor radionuclide therapy (PRRT)&#8221; &#8220;somatostatin receptor radioligand therapy&#8221;.<\/p>\n<h3>How Does Lutetium-177 DOTA-TATE Treat?<\/h3>\n<p>Lu-177 DOTA-TATE treatment uses a drug consisting of DOTA-TATE, a man-made (synthetic) form of the natural somatostatin hormone, and the radioactive element Lutetium-177.<\/p>\n<p>This combined drug is administered to patients intravenously. The drug binds with DOTA-TATE to the surface of neuroendocrine tumors, and with Lutetium-177 a high dose of local radiotherapy is irradiated directly to the tumor.<\/p>\n<p>The goal of Lu-177 DOTA-TATE therapy is to slow or stop tumor growth and reduce some of the symptoms caused by the tumor. Lu-177 DOTA-TATE treatment usually consists of four cycles administered 8 to 12 weeks apart.<\/p>\n<p>In this section, we aim to answer your questions about Lu-177 DOTA-TATE treatment and explain the benefits, risks and alternatives of treatment. If you have a different question or concern, please contact your referring physician.<\/p>\n<h3>Who is Lutetium-177 DODA-TATE Treatment Applied?<\/h3>\n<p>Your physician may recommend this treatment when you have a neuroendocrine tumor that gets worse and stops responding to other treatments. Studies show that lutetium therapy can improve life expectancy and quality and alleviate symptoms and complaints in people with neuroendocrine tumors.<\/p>\n<p>Before starting treatment, a special kidney test called glomerular filtration rate (GFR) will be done to check how well your kidneys are working.<\/p>\n<h3>What Are The Alternative Treatments?<\/h3>\n<p>There are different treatment options that can help patients with neuroendocrine tumors:<\/p>\n<p><strong>Pain relievers: <\/strong>It reduces pain.<\/p>\n<p><strong>Somatostatin analogs<\/strong>\u0131: These are synthetic forms of somatostatin hormone and octreotide etc. includes medications. It is given by injection to relieve tumor-related complaints (symptoms) and to help stop your disease.<\/p>\n<p><strong>Interferon alpha<\/strong>: It is a biological treatment that can help prevent tumor growth and the symptoms it causes. It is given by injection.<\/p>\n<p><strong>Surgery :<\/strong> If the tumor is accessible, surgery can remove the tumor completely or reduce the size of the tumor to improve symptoms.<\/p>\n<p><strong>Chemotherapy :<\/strong> These drugs are used to improve symptoms by reducing tumor size. It is usually given through a vein in the back of the hand or arm. However, most neuroendocrine tumors are not very sensitive to chemotherapy treatment.<\/p>\n<p><strong>Targeted therapies<\/strong> (eg. sunitinib or everolimus); These drugs are taken by mouth to slow tumor growth and metastasis.<\/p>\n<p><strong>Embolisation<\/strong>: It is a technique used to control symptoms by reducing blood flow to the tumor. It can sometimes be used in combination with chemotherapy or radiation therapy to prevent the growth of tumor cells.<\/p>\n<p><strong>Radiofrequency ablation:<\/strong> It is a procedure performed under general anesthesia that uses low electrical current to conduct heat to suppress liver tumors.<\/p>\n<p><strong>Other targeted radionuclide therapies<\/strong>: Radionuclide treatments such as 131I-mIBG.<\/p>\n<p>These treatments can be used one after the other or in combination with the recommendation of your physician. After discussing all treatment options, you can choose to receive or not receive any treatment. In addition, your physician may think that such treatments cannot help you and may recommend palliative care. This helps support you and relieve your symptoms.<\/p>\n<h3>Is Lutetium-177 DOTA-TATE Treatment Safe?<\/h3>\n<p>Our NET patients receiving Lu-177 DOTA-TATE treatment experience minimal and less severe long-term side effects compared to other cancer treatments.<\/p>\n<p>The radiation used in this treatment is designed to directly damage and destroy cancer cells. Since most of Lu-177 DOTA-TATE goes to tumor tissue, damage to <strong>healthy tissues is minimal.<\/strong><\/p>\n<p>However, as radiation can affect the kidney and bone marrow, patients are followed up with post-treatment blood tests.<\/p>\n<p><strong>\u00a0<\/strong>In treatment; In general, two types of side effects may occur, either related to treatment itself or related to the radiation dose to which the body is exposed:<\/p>\n<h3>1. Treatment-Related Possible Side Effects<\/h3>\n<ul>\n<li>You may feel nauseous, usually only on the day of treatment. To prevent this, anti-nausea medications are given beforehand.<\/li>\n<li>Inflammation in the tumor can lead to an increase in pain, which we can see in patients with tumors in the bone, liver or pancreas. This condition usually resolves within 72 hours of treatment. You will need to use low-dose steroids (dexamethasone) to help reduce the symptoms, however we also recommend taking your regular pain medication more regularly.<\/li>\n<li>It may cause a temporary increase in the intensity of your daily symptoms such as flushing, sweating, palpitations or wheezing, and an increased frequency of existing diarrhea. This situation usually stabilizes within 24-48 hours, and you may need to increase the amount of antidiarrheal medication you use.<\/li>\n<li>A few weeks after each course of treatment can make you feel weakly.<\/li>\n<li>Temporary hair thinning is a condition that can be seen in some of our patients, and it returns to normal again after the Lu-177 DOTA-TATE treatment is completed.<\/li>\n<\/ul>\n<p>Of course, it is also possible that you may not feel different than normal and not experience any of these side effects.<\/p>\n<h3>2. Radiation Dosage Related Side Effects<\/h3>\n<p>Although healthy normal cells show a very low amount of Lu-177 DOTA-TATE uptake compared to tumor tissue, the side effects of radiation can also damage these cells.<\/p>\n<p>Lu-177 DOTA-TATE treatment can also affect parts of your body other than tumors. It can particularly affect your bone marrow and kidneys. This may cause you to feel weakly than usual or be more susceptible to infection for a few weeks after treatment.<\/p>\n<p>You will need regular blood tests after each course of treatment to check your blood count (blood cells) and to see how your kidneys and liver are working. Secondary myelodysplastic syndrome and leukemia have been reported, although very rarely.<\/p>\n<p>It is important to tell your physician if you have any new or unexpected health problems after Lu-177 DOTA-TATE treatment, even if they are not listed above.<\/p>\n<h3>Lutetium-177 DOTA-TATE and Pregnancy<\/h3>\n<p>Before starting each course of Lu-177 DOTA-TATE, all women of childbearing age are asked to provide a urine sample for pregnancy testing to exclude the possibility of pregnancy. Both men and women are advised not to become pregnant during their treatment and for at least six months after completing treatment. During this time, reliable contraceptive methods should be used. You can consult your physician for more detailed information.<\/p>\n<h3>What are you asked to do before lutetium-177 DODA-TATE treatment?<\/h3>\n<p>For each course of treatment, you will have several days of hospital visits. You may need to be hospitalized for treatment. Four courses of treatments take eight to ten months to complete. Your control appointment will be scheduled after your last course of treatment is completed. During this period, you should also be in contact with your referring physician who follows you.<\/p>\n<p>Before each course of treatment, you will be asked to have a blood test and a physical examination. These procedures will help us evaluate your suitability for treatment, along with a brief querry about your general health.<\/p>\n<p>You must inform us about all the medicines you use (including those that are not prescribed by your physician). If you are being treated with octreotide (Sandostatin LAR\u00ae) or lanreotide injections, we also need to know the date of your last injection. This is important so that we can plan your Lu-177 DOTA-TATE treatment cycle to deliver in the days just before your injection. If you are injecting octreotide daily, we will let you know when to stop. Unless otherwise stated during your pre-treatment appointment, you can eat and drink on the day of your treatment and take all your other medications normally.<\/p>\n<p>If you need to stay in the hospital overnight after treatment, you will need personal supplies.<\/p>\n<p>The time visitors can spend with you will be limited by radiation. You will be informed about this before starting the treatment. However, children under the age of 16 and pregnant women should not come with you or visit you.<\/p>\n<h3>How is Lutetium-177 DOTA-TATE Treatment Applied?<\/h3>\n<p>Your treatment will be performed by the Nuclear Medicine Department and the entire procedure will take about five hours to complete.<\/p>\n<p>A plastic cannula (a small plastic tube) will be inserted into a vein in your arm. Through this cannula, you will first be given medication to prevent you from nausea feeling, then an amino acid infusion (in drop form) to help protect your kidneys from radioactivity.<\/p>\n<p>Approximately one hour later, the amino acid infusion will be discontinued for Lu-177 DOTA-TATE administration. After the Lu-177 DOTA infusion is completed in approximately 30 minutes, the amino acid infusion will resume and the process will continue for another three hours. After the procedure is completed, the cannula will be removed.<\/p>\n<h3>What To Do After Lutetium-177 DOTA-TATE?<\/h3>\n<p>The next morning, we will be waiting for you at the Nuclear Medicine Department for post-treatment scans. These scans will be done to check that your treatment is going as planned, and scanning may take an hour or two.<\/p>\n<p>After the scans, a healthcare professional from our Nuclear Medicine team will measure your radiation levels and inform you about the precautions to follow when leaving the hospital. These measures are necessary to reduce the radiation dose that people around you may be exposed to. If the radiation level in your body is low enough after the measurement, you can go home.<\/p>\n<h4>After Leaving Hospital<\/h4>\n<p>Be sure to follow the advice given to you on radiation precautions.<\/p>\n<p>After each course of treatment, you will be asked to have a blood test every 2 weeks for 8 to 10 weeks to check the effect of the treatment on your blood cells, kidneys and liver.<\/p>\n<p><strong><em>Return to Work<\/em><\/strong><\/p>\n<p>The type of work you do will be taken into account in deciding when to return to work. Your Nuclear Medicine Physician will discuss this with you.<\/p>\n<p class=\"p3\"><a href=\"https:\/\/www.intheranostics.com\/iletisim\/\"><strong>Please contact us for further details.<\/strong><\/a><\/p>\n<p>[\/et_pb_text][et_pb_accordion disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;%224.4.8%22&#8243; disabled=&#8221;on&#8221;][et_pb_accordion_item title=&#8221;%22TANI&#8221; open=&#8221;on&#8221; open_toggle_text_color=&#8221;%22#0ca7c5%22&#8243; _builder_version=&#8221;%224.4.8%22&#8243; toggle_font=&#8221;%22|700|||||||%22&#8243; toggle_font_size=&#8221;%2218px%22&#8243;]<\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT Nedir, T\u00fcm\u00f6r Oda\u011f\u0131n\u0131 Nas\u0131l G\u00f6sterir?<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b><span style=\"float: none;background-color: #ffffff;color: #666666;font-family: 'Quicksand',Helvetica,Arial,Lucida,sans-serif;font-size: 100%;font-style: normal;font-variant: normal;font-weight: 500;letter-spacing: normal;text-align: left;text-decoration: none;text-indent: 0px;text-transform: none\">Teranostik t\u0131p d\u00fcnyas\u0131nda yeni geli\u015fmekte olan bir aland\u0131r. T\u00fcm\u00f6re \u00f6zg\u00fcl bir ila\u00e7 ile g\u00f6r\u00fcnt\u00fcleme yaparak saptanan t\u00fcm\u00f6r ve metastazlar\u0131n\u0131n, nereye gidece\u011fi, ne kadar gidece\u011fi ve hastal\u0131kl\u0131 dokuyu etkileme g\u00fcc\u00fc \u00f6nceden bilinen yine \u00f6zg\u00fcl bir ila\u00e7 ile tedavi edilebildi\u011fi bir yakla\u015f\u0131md\u0131r. Bu yakla\u015f\u0131m, geleneksel t\u0131ptan ki\u015fiye \u00f6zg\u00fc \u00e7a\u011fda\u015f t\u0131p uygulamalar\u0131na ge\u00e7i\u015f yap\u0131lmas\u0131n\u0131 sa\u011flamaktad\u0131r.<\/span><\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Prostat kanserinden \u00f6l\u00fcmler genellikle kemik metastaz\u0131 ve komplikasyonlar\u0131ndan kaynaklanmaktad\u0131r. Prostat kanseri kemik metastazlar\u0131\u00a0Flor-18 NaF (<\/span><span class=\"s2\"><sup>18<\/sup><\/span><span class=\"s1\">F-NaF) PET\/BT ile y\u00fcksek duyarl\u0131l\u0131kla g\u00f6r\u00fcnt\u00fclenebilmekte ve Radyum-223 ile bu t\u00fcm\u00f6ral dokular\u0131n \u00f6zg\u00fcl ve hedefe y\u00f6nelik tedavisi yap\u0131labilmektedir. Bu, teranostik uygulamalar i\u00e7in olduk\u00e7a ba\u015far\u0131l\u0131 bir \u00f6rnektir.<\/span><\/p>\n<p class=\"p4\"><span class=\"s1\">Hastal\u0131\u011f\u0131n\u0131z\u0131 takip eden hekiminiz, kemik metastazlar\u0131n\u0131n tan\u0131s\u0131 amac\u0131yla size bu tetkiki \u00f6nerebilir.\u00a0F-18 NaF PET\/BT; kemik metastazlar\u0131n\u0131n yeri ve yayg\u0131nl\u0131\u011f\u0131n\u0131 do\u011fru bir \u015fekilde g\u00f6sterirken a\u011fr\u0131l\u0131 kemik metastazlar\u0131nda hedefe y\u00f6nelik ba\u015far\u0131l\u0131 bir tedavi se\u00e7ene\u011fi olan Radyum-223 tedavisinin kullan\u0131m\u0131n\u0131 da m\u00fcmk\u00fcn k\u0131lar.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT\u2019nin \u00dcst\u00fcn Yanlar\u0131 Nelerdir?<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">F-18 NaF PET\/BT, kemik g\u00f6r\u00fcnt\u00fcleme maddesi olarak ideal \u00f6zelliklere sahiptir ve 45-60 dakika gibi k\u0131sa bir s\u00fcre i\u00e7inde \u00fcst\u00fcn kalitede g\u00f6r\u00fcnt\u00fcler \u00fcretir.\u00a0Ba\u015fta kemik metastaz\u0131 ara\u015ft\u0131r\u0131lan hastalar olmak \u00fczere bir\u00e7ok hasta i\u00e7in,\u00a0F-18 NaF PET\/BT, geleneksel kemik sintigrafisine g\u00f6re \u00e7ok daha ba\u015far\u0131l\u0131 sonu\u00e7lar\u0131 ile ideal bir alternatiftir.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT Kimlere Uygulan\u0131r?<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Hastal\u0131\u011f\u0131n\u0131z\u0131 takip eden hekiminiz sizden\u00a0F-18 NaF PET\/BT taramas\u0131n\u0131 \u015fu ama\u00e7lar i\u00e7in isteyebilir:<\/span><\/p>\n<ul>\n<li class=\"p4\"><span class=\"s1\">Kemik metastazlar\u0131n\u0131n belirlenmesi<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">Hastal\u0131\u011f\u0131n yayg\u0131nl\u0131\u011f\u0131n\u0131n do\u011fru belirlenmesi<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">Malign kemik lezyonlar\u0131n\u0131n yerinin belirlenmesi<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">Kemik a\u011fr\u0131lar\u0131n\u0131n sa\u011falt\u0131m\u0131 i\u00e7in Radyum-223 tedavisinin uygun olup olmad\u0131\u011f\u0131n\u0131n belirlenmesi<\/span><\/li>\n<li class=\"p4\">Tedavi yan\u0131t\u0131n\u0131n de\u011ferlendirilmesi<\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT G\u00fcvenli midir?<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">F-18 NaF bilinen yan etkisi olmayan g\u00fcvenli bir radyoaktif maddedir. Bu i\u015flemde al\u0131nan radyasyon dozu azd\u0131r ve g\u00fcn sonunda v\u00fccudunuzdan temizlenir. N\u00fckleer T\u0131p klini\u011finden ayr\u0131lman\u0131z birka\u00e7 saat s\u00fcrmektedir. PET\/BT taramas\u0131n\u0131 izleyen 6 saat boyunca ba\u015fkalar\u0131yla (\u00f6zellikle \u00e7ocuklar ve hamile kad\u0131nlar) temas\u0131n\u0131z\u0131 en aza indirmenizi \u00f6nermekteyiz.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT \u00d6ncesi Haz\u0131rl\u0131k<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">F-18 NaF PET\/BT g\u00f6r\u00fcnt\u00fclemesi \u00f6ncesinde N\u00fckleer T\u0131p b\u00f6l\u00fcm\u00fcne iletmek \u00fczere, hastal\u0131\u011f\u0131n\u0131za y\u00f6nelik baz\u0131 tetkik ve bilgileri yan\u0131n\u0131zda bulundurman\u0131z istenecektir:<\/span><\/p>\n<ul>\n<li class=\"p4\"><span class=\"s1\">Hekim istem formu<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">Prostat kanseri hikayeniz (\u00f6rn. PSA, patoloji sonu\u00e7lar\u0131)<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">\u00d6nceki onkolojik tedavilerinizin tipi ve tarihi (\u00f6rn. kemoterapi ve\/veya radyoterapi)<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">\u00d6nceki k\u0131r\u0131klar\u0131n\u0131z veya yak\u0131n tarihli travma hikayeniz (yeri ve tarihi)<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">\u00d6nceki ortopedik cerrahi giri\u015fimleriniz (m\u00fcdahale tarihi, tipi ve yeri)<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">\u00d6nceki enfeksiyon ve yeri<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">\u0130drar yolu ile ilgili ge\u00e7irilmi\u015f ameliyatlar<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">Her bir kemik a\u011fr\u0131n\u0131z\u0131n yeri<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">Di\u011fer g\u00f6r\u00fcnt\u00fclemeler ve raporlar\u0131 (\u00f6zellikle kemik sintigrafisi, BT veya MRI)<\/span><\/li>\n<\/ul>\n<p class=\"p2\"><span class=\"s1\">F-18 NaF PET\/BT i\u015flemi i\u00e7in a\u00e7 olman\u0131za gerek yoktur. \u0130la\u00e7lar\u0131n\u0131z\u0131 her zamanki gibi alabilirsiniz. <\/span><span class=\"s1\">B\u00f6brekten at\u0131l\u0131m\u0131 art\u0131rmak, al\u0131nan radyasyon dozunu azaltmak ve en iyi g\u00f6r\u00fcnt\u00fc kalitesine ula\u015fmak i\u00e7in,\u00a0F-18 NaF enjeksiyonu \u00f6ncesinde ve sonras\u0131nda en az iki\u015fer bardak su i\u00e7melisiniz. Tetkik sonras\u0131nda g\u00fcn\u00fcn geri kalan\u0131nda da su i\u00e7meye devam etmeniz faydal\u0131 olacakt\u0131r.\u00a0\u0130\u015flem s\u0131ras\u0131nda g\u00f6r\u00fcnt\u00fc bozulmalar\u0131n\u0131 \u00f6nlemek i\u00e7in t\u00fcm metal e\u015fyalar\/tak\u0131lar\/protezler \u00e7\u0131kar\u0131lmal\u0131d\u0131r.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT Nas\u0131l Uygulan\u0131r?<\/b><\/span><\/p>\n<p class=\"p4\"><span class=\"s1\">Az miktarda (1.5-3.7 Mbq\/Kg (0.04-0.1 mCi\/Kg) dozunda) F-18-NaF, g\u00f6r\u00fcnt\u00fcleme i\u015fleminden yakla\u015f\u0131k 30-60 dakika \u00f6nce, kol ya da el s\u0131rt\u0131n\u0131za yerle\u015ftirdi\u011fimiz damar yolundan uygulanacakt\u0131r.\u00a0<\/span><span class=\"s1\">F-18 NaF PET\/BT g\u00f6r\u00fcnt\u00fclemesinden hemen \u00f6nce mesanenizi bo\u015faltman\u0131z gerekmektedir.<\/span><\/p>\n<p class=\"p4\"><span class=\"s1\">PET\/BT g\u00f6r\u00fcnt\u00fclemesi boyunca (yakla\u015f\u0131k 20-25 dk.), v\u00fccut g\u00f6r\u00fcnt\u00fclerinin s\u00fcrekli kaydedildi\u011fi, her iki ucu a\u00e7\u0131k, geni\u015f halka \u015feklindeki bir cihazda, \u00f6zel \u00e7ekim yata\u011f\u0131 \u00fczerinde uzanman\u0131z istenecektir. \u0130\u015flemin tek zahmetli yan\u0131; bu s\u00fcre zarf\u0131nda hareketsiz kalman\u0131zd\u0131r. \u0130htiyac\u0131n\u0131z halinde, g\u00f6r\u00fcnt\u00fcleme \u00f6ncesi, beraberinizde getirdi\u011finiz a\u011fr\u0131 kesicinizi kullanabilirsiniz.<\/span><\/p>\n<p class=\"p4\"><span class=\"s1\">\u0130htiya\u00e7 duyulursa uzmanlar\u0131m\u0131z ek g\u00f6r\u00fcnt\u00fc alabilir. Ek g\u00f6r\u00fcnt\u00fcleme i\u015flemi yakla\u015f\u0131k 10-15 dakika s\u00fcrmektedir. <\/span><span class=\"s1\">N\u00fckleer T\u0131p klini\u011findeki i\u015flemlerin tamamlanmas\u0131 birka\u00e7 saati bulabilir. <\/span><span class=\"s1\">Kolunuzdaki damar yolu, g\u00f6r\u00fcnt\u00fclemeniz tamamland\u0131ktan ve t\u00fcm g\u00f6r\u00fcnt\u00fcleriniz kontrol edildikten sonra \u00e7\u0131kart\u0131lacakt\u0131r. Sa\u011fl\u0131k personelimizin onay vermesiyle, N\u00fckleer T\u0131p b\u00f6l\u00fcm\u00fcnden art\u0131k g\u00fcvenle ayr\u0131labilirsiniz.<\/span><\/p>\n<p class=\"p4\"><span class=\"s1\">\u0130la\u00e7 verildikten sonra ilk 6 saat k\u00fc\u00e7\u00fck \u00e7ocuklarla ve hamile kad\u0131nlarla temastan ka\u00e7\u0131nman\u0131z gerekti\u011fini l\u00fctfen unutmay\u0131n\u0131z. G\u00f6r\u00fcnt\u00fcleriniz N\u00fckleer T\u0131p Uzmanlar\u0131m\u0131z taraf\u0131ndan belirtilen s\u00fcrede de\u011ferlendirilerek rapor edilecektir.<\/span><\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;TEDAV\u0130 H\u0130ZMETLER\u0130 &#8211; RADYUM-223 TEDAV\u0130S\u0130&#8221; open_toggle_text_color=&#8221;#0ca7c5&#8243; _builder_version=&#8221;4.4.8&#8243; toggle_font=&#8221;|700|||||||&#8221; toggle_font_size=&#8221;18px&#8221; open=&#8221;off&#8221;]<\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi Nedir?<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Teranostik t\u0131p d\u00fcnyas\u0131nda yeni geli\u015fmekte olan bir aland\u0131r. T\u00fcm\u00f6re \u00f6zg\u00fcl bir ila\u00e7 ile g\u00f6r\u00fcnt\u00fcleme yaparak saptanan t\u00fcm\u00f6r ve metastazlar\u0131n\u0131n, nereye gidece\u011fi-ne kadar gidece\u011fi ve hastal\u0131kl\u0131 dokuyu etkileme g\u00fcc\u00fc \u00f6nceden bilinen yine \u00f6zg\u00fcl bir ila\u00e7 ile tedavi edilebildi\u011fi bir yakla\u015f\u0131md\u0131r. Bu yakla\u015f\u0131m, geleneksel t\u0131ptan ki\u015fiye \u00f6zg\u00fc \u00e7a\u011fda\u015f t\u0131p uygulamalar\u0131na ge\u00e7i\u015f yap\u0131lmas\u0131n\u0131 sa\u011flamaktad\u0131r.<\/span><\/p>\n<p class=\"p2\">Prostat kanseri<strong>\u00a0<\/strong>v\u00fccudun di\u011fer b\u00f6lgelerine yay\u0131ld\u0131\u011f\u0131nda, s\u0131kl\u0131kla kemiklerde yerle\u015fmektedir. Kemik metastaz\u0131 a\u011fr\u0131 d\u0131\u015f\u0131nda, k\u0131r\u0131k, omurilik s\u0131k\u0131\u015fmas\u0131 veya hayat\u0131 tehdit edebilen y\u00fcksek kan kalsiyum seviyeleri gibi ba\u015fka sorunlara da neden olabilir. Kanser kemiklere ula\u015ft\u0131\u011f\u0131nda, a\u011fr\u0131y\u0131 ve di\u011fer komplikasyonlar\u0131 kontrol etmek veya hafifletmek tedavinin \u00e7ok \u00f6nemli bir par\u00e7as\u0131d\u0131r. Hormon tedavisi, kemoterapi ve a\u015f\u0131lar gibi tedaviler buna yard\u0131mc\u0131 olabilir. Ancak uygun hastalarda, \u00f6zellikle kemik metastaz\u0131n\u0131 hedef alan ve alfa \u0131\u015f\u0131mas\u0131 yapan Radyum-223 tedavisi ile bir yandan semptomlar kontrol alt\u0131na al\u0131n\u0131rken bir yandan da sa\u011f kal\u0131m\u0131 art\u0131r\u0131c\u0131 etki sa\u011flanabilmektedir.<\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Nas\u0131l Tedavi Eder?<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Radyum-223, kemik metastazlar\u0131na se\u00e7ici olarak ba\u011flanan ve \u00e7ok k\u0131sa menzilli y\u00fcksek enerjili par\u00e7ac\u0131klar\u0131 (&lt;100 \u03bcm) yayan, radyoaktif bir elementtir. Radyum-223 diklor\u00fcr molek\u00fcl\u00fc, kalsiyumu taklit ederek kemik metastazlar\u0131na ba\u011flan\u0131r ve ard\u0131ndan y\u00fcksek enerjili alfa par\u00e7ac\u0131\u011f\u0131na ait radyasyon, DNA k\u0131r\u0131klar\u0131na neden olarak t\u00fcm\u00f6r h\u00fccrelerini \u00f6ld\u00fcr\u00fcr. Alfa par\u00e7ac\u0131klar\u0131n\u0131n k\u0131sa olan menzili, kom\u015fu sa\u011fl\u0131kl\u0131 doku ve \u00f6zellikle kemik ili\u011fi \u00fczerindeki zararl\u0131 etkinin de en az d\u00fczeyde kalmas\u0131 anlam\u0131na gelmektedir.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Sa\u011f kal\u0131m\u0131 uzatt\u0131\u011f\u0131 bilinen kemi\u011fe \u00f6zg\u00fc tek ila\u00e7, radyoaktif alfa par\u00e7ac\u0131\u011f\u0131 yayarak tedavi edici etkisini g\u00f6steren Radyum-223&#8217;t\u00fcr. Bilimsel \u00e7al\u0131\u015fmalar ile Radyum-223 tedavisinin ortalama ya\u015fam s\u00fcresini uzatt\u0131\u011f\u0131 g\u00f6sterilmi\u015ftir. Buna ek olarak a\u011fr\u0131da ve ya\u015fam kalitesinde iyile\u015fmeyi sa\u011flamaktad\u0131r. T\u00fcm bu faydalar\u0131n\u0131n yan\u0131nda kan de\u011ferlerinde ge\u00e7ici d\u00fc\u015fme ve ishal d\u0131\u015f\u0131nda Radyum-223 tedavisi ile ili\u015fkili yan etkiler olduk\u00e7a hafif d\u00fczeylerde izlenmi\u015ftir.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi Kimlere Uygulan\u0131r?<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisi \u00e7ok spesifik bir tedavi t\u00fcr\u00fcd\u00fcr, bu nedenle sadece kemiklere yay\u0131lm\u0131\u015f ve a\u011fr\u0131 \u015fikayeti olan prostat kanserli hastalarda, takip eden hekimleri taraf\u0131ndan uygun g\u00f6r\u00fclmesi durumunda uygulanabilir.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisi, kemi\u011fe yay\u0131lm\u0131\u015f kanserin s\u0131kl\u0131kla neden oldu\u011fu a\u011fr\u0131y\u0131 hafifletebilir. Bu tedavinin uygulanmas\u0131na karar verildi\u011finde, tedavi \u00f6ncesinde, t\u00fcm v\u00fccut kemik taramas\u0131 (\u00f6rn. F-NaF PET\/BT, kemik sintigrafisi) yap\u0131lmaktad\u0131r. Bu, Radyum-223&#8217;\u00fcn tedavi s\u0131ras\u0131nda do\u011fru alanlar\u0131 hedefledi\u011finden emin olunmas\u0131n\u0131 sa\u011flayacakt\u0131r.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi G\u00fcvenli midir?<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisinde kullan\u0131lan alfa radyasyonu \u00e7ok y\u00fcksek bir enerji seviyesine sahiptir. Bununla birlikte alfa radyasyon, do\u011fas\u0131 gere\u011fi sadece \u00e7ok k\u0131sa mesafelere (iki ila on h\u00fccre mesafesinde) seyahat eder ve bu da radyasyonun yok edici etkisinin sa\u011fl\u0131kl\u0131 h\u00fccrelerde de\u011fil, kemikteki kanser h\u00fccrelerinde olu\u015fmas\u0131n\u0131 sa\u011flamaktad\u0131r. Sa\u011fl\u0131kl\u0131 h\u00fccrelerce al\u0131nan minimal radyasyon dozu, Radium-223 tedavisi ile ili\u015fkili yan etkilerin de ihmal edilebilir d\u00fczeyde oldu\u011fu anlam\u0131na gelir ve \u00fcretilen kan h\u00fccrelerinin say\u0131s\u0131nda ge\u00e7ici bir azalma ve nadiren bulant\u0131, kusma ve ishal, tedavi olan hastalar\u0131m\u0131zda g\u00f6r\u00fclebilmektedir.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi \u00d6ncesi Haz\u0131rl\u0131k \u00a0<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Klini\u011fe ilk ba\u015fvurunuzda, a\u015fa\u011f\u0131da listelenen bilgi ve belgeleri beraberinizde getirmeniz \u00f6nemlidir. Hasta bilgilerinizin dijital ortamda haz\u0131rlanmas\u0131 (DICOM, JPEG, PNG, PDF, Microsoft Word (.doc, .docx, vb.)), e-posta ile h\u0131zl\u0131 ve kolayca payla\u015f\u0131lmas\u0131na imkan tan\u0131yacak ve hastal\u0131\u011f\u0131n\u0131z\u0131n de\u011ferlendirilmesini b\u00fcy\u00fck oranda kolayla\u015ft\u0131racakt\u0131r:<\/span><\/p>\n<ul>\n<li class=\"p2\"><span class=\"s1\">Sizin ve sizi takip eden hekiminizin ileti\u015fim bilgileri (ev\/i\u015f\/cep telefon numaras\u0131, e-posta adresi)<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">En g\u00fcncel hekim raporlar\u0131<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Patoloji raporlar\u0131<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Kan testleri<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">T\u00fcm v\u00fccut kemik sintigrafisi, BT, MR ve 68Ga-PSMA PET\/BT, 18F-FDG PET\/BT raporlar\u0131 ve orijinal film\/CD\/DVD&#8217;leri<\/span><\/li>\n<\/ul>\n<p class=\"p2\"><span class=\"s1\">N\u00fckleer T\u0131p Hekiminiz, bu tedavi \u00f6ncesinde ihtiya\u00e7 duyulmas\u0131 halinde, tedaviye uygunlu\u011funuzu de\u011ferlendirmek amac\u0131yla 18F-NaF PET\/BT veya t\u00fcm v\u00fccut kemik sintigrafisi g\u00f6r\u00fcnt\u00fclemeleri ile kemik erimesi varl\u0131\u011f\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 i\u00e7in kemik mineral yo\u011funlu\u011fu \u00f6l\u00e7\u00fcm\u00fc isteyebilir.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Ayr\u0131ca a\u015fa\u011f\u0131daki kan testlerini yapt\u0131rman\u0131z istenecektir. Bu testlerin, tedavi s\u0131ras\u0131ndaki durumunuzu g\u00f6stermesi beklendi\u011finden, tedaviden en ge\u00e7 2 hafta \u00f6nce yap\u0131lm\u0131\u015f olmas\u0131 gerekmektedir. Bu testler tedaviye ba\u015flarken ve her tedavi k\u00fcr\u00fcnden \u00f6nce yap\u0131lacakt\u0131r.<\/span><\/p>\n<ul>\n<li class=\"p2\"><span class=\"s1\">PSA<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Tam kan say\u0131m\u0131<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Alkalen fosfataz<\/span><\/li>\n<\/ul>\n<p class=\"p2\"><span class=\"s1\">Hekiminiz, gerekti\u011finde ek kan testleri de isteyebilir. <\/span><span class=\"s1\">Karaci\u011fer ve b\u00f6brek yetmezli\u011fi olan hastalar\u0131m\u0131zda, Radyum-223 tedavisi herhangi bir doz ayarlamas\u0131na gitmeden uygulanabilir.<\/span><span class=\"s1\">Kemik k\u0131r\u0131\u011f\u0131 ya da omurilik bas\u0131s\u0131 olan hastalar\u0131m\u0131zda ise \u00f6ncelikle bu sorunlar\u0131n d\u00fczeltilmesi istenecektir.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Kemoterapi tedavisi ald\u0131ysan\u0131z en son k\u00fcr\u00fcn \u00fczerinden en az 4 hafta ge\u00e7ti\u011finden emin olman\u0131z gerekmektedir.<\/span><span class=\"s1\">Tedavi s\u0131ras\u0131nda evden getirdi\u011finiz kendi giysilerinizi giyece\u011finiz i\u00e7in rahat ve geni\u015f k\u0131yafetler tercih etmenizi \u00f6neririz. Tedaviniz ve birlikte yap\u0131lan testler i\u00e7in kolunuza veya elinizin s\u0131rt\u0131na yerle\u015ftirilen damar yolu kullan\u0131laca\u011f\u0131ndan, k\u0131sa kollu ya da geni\u015f kollu giysileri bulundurman\u0131z yararl\u0131 olacakt\u0131r.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Radyum-223 ba\u011f\u0131rsaktan at\u0131ld\u0131\u011f\u0131 i\u00e7in \u201c\u00fclseratif kolit\u201d ve \u201cCrohn hastal\u0131\u011f\u0131\u201d gibi enflamatuar ba\u011f\u0131rsak hastal\u0131\u011f\u0131 olan ya da ba\u011f\u0131rsak t\u0131kan\u0131kl\u0131\u011f\u0131 hikayesi bulunan hastalar\u0131m\u0131zda ek destekleyici \u00f6nlemler almam\u0131z gerekebilir.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi Nas\u0131l Uygulan\u0131r?<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Standard Radyum-223 tedavisi; d\u00f6rt haftal\u0131k aral\u0131klarla, toplam alt\u0131 tedavi k\u00fcr\u00fcnden (6 adet, birer dakikal\u0131k enjeksiyon) olu\u015fmaktad\u0131r. <\/span><span class=\"s1\">Sizin i\u00e7in \u00fcretilmi\u015f, kullan\u0131ma haz\u0131r Radyum-223 diklor\u00fcr \u00e7\u00f6zeltisi, N\u00fckleer T\u0131p Klini\u011finde, yerle\u015ftirdi\u011fimiz periferik damar yoluyla enjekte edilecektir.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Radyum-223 uygulamadan \u00f6nce, damar yolunuzun a\u00e7\u0131kl\u0131\u011f\u0131, en az 10 ml serum fizyolojik ile y\u0131kanarak kontrol edilecek ve Radyum-223 yakla\u015f\u0131k 1 dakika boyunca yava\u015f enjeksiyon \u015feklinde uygulanacak, sonras\u0131nda damar yolunuz yine en az 10 ml serum fizyolojik ile y\u0131kanacakt\u0131r. Bu i\u015flem s\u0131ras\u0131nda a\u011fr\u0131 hissedilmemektedir.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Enjeksiyondan sonra Radyum-223 diklor\u00fcr h\u0131zla kandan temizlenecek ve \u00f6ncelikle kemik ve kemik metastazlar\u0131nda tutulacak veya ba\u011f\u0131rsa\u011fa at\u0131lacakt\u0131r.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Olas\u0131 Yan Etkiler ve Talimatlar<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisi uygulanan hastalar\u0131m\u0131zda g\u00f6r\u00fclebilecek en yayg\u0131n yan etkiler (\u2265% 10) bulant\u0131, kusma ve ishaldir. Ayr\u0131ca kan h\u00fccre say\u0131s\u0131nda ge\u00e7ici d\u00fc\u015fmeler g\u00f6r\u00fclebilmektedir.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Tedavi alan hastalar\u0131m\u0131z\u0131n a\u015fa\u011f\u0131daki talimatlara uymalar\u0131 \u00f6nemlidir:\u00a0\u00a0<\/span><\/p>\n<ul>\n<li class=\"p2\"><span class=\"s1\">Size belirtilen tarihlerde kan say\u0131m\u0131n\u0131z\u0131 yapt\u0131r\u0131n\u0131z. Kanama veya enfeksiyon belirtilerini hekiminize iletiniz.<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">A\u011f\u0131zdan su al\u0131m\u0131n\u0131z iyi d\u00fczeyde olmal\u0131d\u0131r, v\u00fccut su d\u00fczeyi ve idrar \u00e7\u0131k\u0131\u015f\u0131n\u0131z\u0131 takip ediniz.<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">V\u00fccudunuzun susuz kalmas\u0131 veya b\u00f6brek yetmezli\u011fi belirtileri geli\u015firse hekiminize bildiriniz.<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Tedavi sonras\u0131 di\u011fer insanlarla temas konusunda herhangi bir k\u0131s\u0131tlaman\u0131z yoktur.<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Radyum-223 al\u0131rken ve son enjeksiyondan sonra en az 1 hafta boyunca iyi hijyen uygulamalar\u0131na dikkat ediniz.<br \/>\n<\/span><span class=\"s1\">&#8211; Klozeti oturarak kullan\u0131n\u0131z ve her kullan\u0131mdan sonra sifonu en az 2 kez \u00e7ekiniz.<br \/>\n<\/span><span class=\"s1\">&#8211; \u0130drar ve d\u0131\u015fk\u0131 ile kirlenmi\u015f giysilerinizi derhal ve di\u011fer k\u0131yafetlerden ayr\u0131 olarak y\u0131kay\u0131n\u0131z.<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Bak\u0131c\u0131lar\u0131n\u0131z, bula\u015f\u0131 \u00f6nlemek i\u00e7in v\u00fccut s\u0131v\u0131lar\u0131n\u0131z\u0131 tutarken eldiven kullanmal\u0131, sonras\u0131nda ellerini y\u0131kamal\u0131d\u0131r.<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Cinsel olarak aktif olan hastalar\u0131m\u0131z prezervatif kullanmal\u0131 ve \u00fcreme potansiyeli olan kad\u0131n partnerleri de tedavi s\u0131ras\u0131nda ve tedavinin tamamlanmas\u0131n\u0131 takip eden 6 ay boyunca etkili bir do\u011fum kontrol y\u00f6ntemi uygulamal\u0131d\u0131r.<\/span><\/li>\n<\/ul>\n<p class=\"p2\"><span class=\"s1\"><i>Daha fazla bilgi i\u00e7in l\u00fctfen bizimle irtibata ge\u00e7iniz.<\/i><\/span><\/p>\n<p>[\/et_pb_accordion_item][\/et_pb_accordion][et_pb_code _builder_version=&#8221;4.4.8&#8243;][\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.4.8&#8243; background_color=&#8221;rgba(0,0,0,0)&#8221; background_image=&#8221;https:\/\/www.intheranostics.com\/wp-content\/uploads\/2020\/06\/metastatik_prostat_kanseri.jpg&#8221; custom_padding=&#8221;100px||100px||false|false&#8221; locked=&#8221;off&#8221;][et_pb_fullwidth_header title=&#8221;Lutetium-177 DOTA-TATE&#8221; text_orientation=&#8221;center&#8221; content_max_width_last_edited=&#8221;off|desktop&#8221; _builder_version=&#8221;4.4.8&#8243; title_font_size=&#8221;50px&#8221; content_font_size=&#8221;41px&#8221; subhead_font=&#8221;|700|||||||&#8221; subhead_font_size=&#8221;38px&#8221; subhead_line_height=&#8221;1.1em&#8221; background_enable_color=&#8221;off&#8221; background_enable_image=&#8221;off&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221;][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.4.8&#8243; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221;][et_pb_row _builder_version=&#8221;4.4.8&#8243; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.4.8&#8243;][et_pb_divider divider_weight=&#8221;0px&#8221; _builder_version=&#8221;4.4.8&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_start=&#8221;#8dd2e1&#8243; background_color_gradient_end=&#8221;#23afca&#8221; background_color_gradient_direction=&#8221;90deg&#8221; width=&#8221;50%&#8221; module_alignment=&#8221;center&#8221; height=&#8221;10px&#8221;][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; _builder_version=&#8221;4.4.8&#8243;][et_pb_row admin_label=&#8221;row&#8221; _builder_version=&#8221;4.4.8&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" fullwidth=\"on\" _builder_version=\"4.4.8\" background_color=\"rgba(0,0,0,0)\" background_image=\"https:\/\/www.intheranostics.com\/wp-content\/uploads\/2020\/06\/metastatik_prostat_kanseri.jpg\" custom_padding=\"100px||100px||false|false\" locked=\"off\"][et_pb_fullwidth_header title=\"Lutesyum-177 DOTA-TATE\" text_orientation=\"center\" content_max_width_last_edited=\"off|desktop\" _builder_version=\"4.4.8\" title_font_size=\"50px\" content_font_size=\"41px\" subhead_font=\"|700|||||||\" subhead_font_size=\"38px\" subhead_line_height=\"1.1em\" background_enable_color=\"off\" background_enable_image=\"off\" custom_margin=\"||||false|false\" custom_padding=\"||||false|false\" animation_style=\"slide\" animation_direction=\"bottom\" hover_enabled=\"0\"][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.4.8\" custom_margin=\"0px||0px||false|false\" custom_padding=\"0px|0px|0px|0px|false|false\"][et_pb_row _builder_version=\"4.4.8\" custom_margin=\"0px||||false|false\" custom_padding=\"0px|0px|0px|0px|false|false\"][et_pb_column type=\"4_4\" _builder_version=\"4.4.8\"][et_pb_divider divider_weight=\"0px\" _builder_version=\"4.4.8\" use_background_color_gradient=\"on\" background_color_gradient_start=\"#8dd2e1\" background_color_gradient_end=\"#23afca\" background_color_gradient_direction=\"90deg\" width=\"50%\" module_alignment=\"center\" height=\"10px\"][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" admin_label=\"section\" _builder_version=\"4.4.8\"][et_pb_row admin_label=\"row\" _builder_version=\"4.4.8\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_margin=\"||||false|false\" custom_padding=\"0px|0px|0px|0px|false|false\"][et_pb_column type=\"4_4\" _builder_version=\"3.25\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.4.8\" hover_enabled=\"0\"]<h2 class=\"p1\"><span class=\"s1\"><b>Lutesyum-177 DOTA-TATE Tedavisi Nedir?<\/b><\/span><\/h2>\r\n<p class=\"p3\"><span class=\"s1\">N\u00f6roendokrin t\u00fcm\u00f6rler (NET); ba\u015fta ba\u011f\u0131rsak, pankreas ve akci\u011ferler olmak \u00fczere, v\u00fccudun herhangi bir yerinde ortaya \u00e7\u0131kabilen, nadir g\u00f6r\u00fclen kanserlerdir.<\/span><\/p>\r\n<p class=\"p4\">Teranostik t\u0131p d\u00fcnyas\u0131nda yeni geli\u015fmekte olan bir aland\u0131r. T\u00fcm\u00f6re \u00f6zg\u00fcl bir ila\u00e7 ile g\u00f6r\u00fcnt\u00fcleme yaparak saptanan t\u00fcm\u00f6r ve metastazlar\u0131n\u0131n, nereye gidece\u011fi-ne kadar gidece\u011fi ve hastal\u0131kl\u0131 dokuyu etkileme g\u00fcc\u00fc \u00f6nceden bilinen yine \u00f6zg\u00fcl bir ila\u00e7 ile tedavi edilebildi\u011fi bir yakla\u015f\u0131md\u0131r. Bu yakla\u015f\u0131m, geleneksel t\u0131ptan ki\u015fiye \u00f6zg\u00fc \u00e7a\u011fda\u015f t\u0131p uygulamalar\u0131na ge\u00e7i\u015f yap\u0131lmas\u0131n\u0131 sa\u011flamaktad\u0131r.<\/p>\r\n<p class=\"p4\"><span class=\"s1\">Teranostik uygulamalarda baz\u0131 g\u00f6r\u00fcnt\u00fcleme ajanlar\u0131 kullan\u0131larak, n\u00f6roendokrin t\u00fcm\u00f6rlerin tan\u0131-tedavisi yap\u0131labilir. Bu ajanlardan Ga-68 DOTA-TATE PET\/BT ile t\u00fcm\u00f6ral dokular y\u00fcksek duyarl\u0131l\u0131kta g\u00f6r\u00fcnt\u00fclenebilmekte, Lu-177 DOTA-TATE ile t\u00fcm\u00f6ral dokular\u0131n \u00f6zg\u00fcl ve hedefe y\u00f6nelik tedavisi yap\u0131labilmektedir.\u00a0<\/span><span class=\"s2\">Bu, teranostik uygulamalar i\u00e7in olduk\u00e7a ba\u015far\u0131l\u0131 ve yeni bir y\u00f6ntemdir.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\">Lu-177 DOTA-TATE; n\u00f6roendokrin t\u00fcm\u00f6rlerde kullan\u0131lan bir tedavi y\u00f6ntemidir. \u201cHedeflenmi\u015f radyon\u00fcklid tedavi\u201d, \u201cpeptit resept\u00f6r\u00fc radyon\u00fcklid tedavi (PRRT)\u201d \u201csomatostatin resept\u00f6r radyoligand tedavisi\u201d gibi farkl\u0131 isimlerle de an\u0131lmaktad\u0131r.<\/span><\/p>\r\n<h3 class=\"p1\"><span class=\"s1\"><b>Lutesyum-177 DOTA-TATE Nas\u0131l Tedavi Eder?<\/b><\/span><\/h3>\r\n<p class=\"p3\"><span class=\"s1\">Lu-177 DOTA-TATE tedavisinde; do\u011fal somatostatin hormonunun, insan yap\u0131m\u0131 (sentetik) bir formu olan DOTA-TATE ile Lutesyum-177 radyoaktif elementinden olu\u015fan bir ila\u00e7 kullan\u0131l\u0131r.\u00a0<\/span><span class=\"s1\">Bu kombine ila\u00e7 hastalara damar yoluyla uygulan\u0131r. \u0130la\u00e7, DOTA-TATE ile n\u00f6roendokrin t\u00fcm\u00f6rlerin y\u00fczeyine ba\u011flan\u0131r ve Lutesyum-177 ile do\u011frudan t\u00fcm\u00f6re, y\u00fcksek bir lokal radyoterapi dozu uygulan\u0131r.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\">Lu-177 DOTA-TATE tedavisinin amac\u0131; t\u00fcm\u00f6r b\u00fcy\u00fcmesini yava\u015flatmak veya durdurmak ve t\u00fcm\u00f6r\u00fcn neden oldu\u011fu baz\u0131 semptomlar\u0131 azaltmakt\u0131r. Lu-177 DOTA-TATE tedavisi genellikle 8 ila 12 hafta arayla uygulanan d\u00f6rt k\u00fcrden olu\u015fmaktad\u0131r.<\/span><\/p>\r\n<p class=\"p6\"><span class=\"s1\">Bu b\u00f6l\u00fcmde Lu-177 DOTA-TATE tedavisi hakk\u0131ndaki sorular\u0131n\u0131z\u0131 yan\u0131tlamay\u0131, tedavinin faydalar\u0131, riskleri ve alternatiflerini a\u00e7\u0131klamay\u0131 ama\u00e7lamaktay\u0131z. Farkl\u0131 bir soru veya endi\u015feniz varsa, l\u00fctfen sizi takip eden hekimizle g\u00f6r\u00fc\u015f\u00fcn\u00fcz.<\/span><\/p>\r\n<h3 class=\"p1\"><span class=\"s1\"><b>Lutesyum-177 DODA-TATE Tedavisi Kimlere Uygulan\u0131r?<\/b><\/span><\/h3>\r\n<p class=\"p3\"><span class=\"s1\">Hekiminiz, daha da k\u00f6t\u00fcle\u015fen ve di\u011fer tedavilere yan\u0131t vermeyi b\u0131rakan bir n\u00f6roendokrin t\u00fcm\u00f6r\u00fcn\u00fcz oldu\u011funda bu tedaviyi size \u00f6nerebilir. Ara\u015ft\u0131rmalar, lutetium tedavisinin n\u00f6roendokrin t\u00fcm\u00f6r\u00fc olan insanlarda; ya\u015fam beklentisini ve kalitesini art\u0131rabilece\u011fini, semptom ve \u015fikayetleri hafifletebilece\u011fini g\u00f6stermektedir.\u00a0<\/span><span class=\"s1\">Tedaviye ba\u015flamadan \u00f6nce, b\u00f6breklerinizin ne kadar iyi \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 kontrol etmek i\u00e7in glomer\u00fcler filtrasyon h\u0131z\u0131 (GFR) ad\u0131 verilen \u00f6zel bir b\u00f6brek testi yapt\u0131r\u0131lacakt\u0131r.<\/span><\/p>\r\n<h3 class=\"p9\"><span class=\"s1\"><b>Alternatif Tedaviler Nelerdir?<\/b><\/span><\/h3>\r\n<p class=\"p3\"><span class=\"s1\">N\u00f6roendokrin t\u00fcm\u00f6r\u00fc olan hastalara yard\u0131mc\u0131 olabilecek farkl\u0131 tedavi imkanlar\u0131 bulunmaktad\u0131r:<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\"><b>A\u011fr\u0131 kesiciler<\/b>: A\u011fr\u0131y\u0131 azalt\u0131r.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\"><b>Somatostatin analoglar<\/b>\u0131: Bunlar somatostatin hormonunun sentetik formlar\u0131d\u0131r ve oketreotid vb. ila\u00e7lar\u0131 i\u00e7erir. T\u00fcm\u00f6re ba\u011fl\u0131 \u015fikayetlerinin (semptomlar\u0131n) giderilmesi ve hastal\u0131\u011f\u0131n\u0131z\u0131n durdurulmas\u0131nda yard\u0131mc\u0131 olmak i\u00e7in enjeksiyonla verilir.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\"><b>\u0130nterferon alfa<\/b>: T\u00fcm\u00f6r b\u00fcy\u00fcmesini ve neden oldu\u011fu semptomlar\u0131 \u00f6nlemeye yard\u0131mc\u0131 olabilecek biyolojik bir tedavidir. Enjeksiyon ile verilir.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\"><b>Cerrahi<\/b>: T\u00fcm\u00f6r eri\u015filebilir durumdaysa, cerrahiyle t\u00fcm\u00f6r tamamen \u00e7\u0131kar\u0131labilir veya t\u00fcm\u00f6r boyutu k\u00fc\u00e7\u00fclt\u00fclerek semptomlar iyile\u015ftirilebilir.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\"><b>Kemoterapi<\/b>: T\u00fcm\u00f6r boyutunu azaltarak semptomlar\u0131 iyile\u015ftirmek i\u00e7in kullan\u0131lan ila\u00e7lard\u0131r. Genellikle bir damla yoluyla el s\u0131rt\u0131ndan veya kolunuzdan verilir. Ancak n\u00f6roendokrin t\u00fcm\u00f6rlerin \u00e7o\u011fu kemoterapi tedavisine \u00e7ok da duyarl\u0131 de\u011fildir.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\"><b>Hedefe y\u00f6nelik tedaviler<\/b>\u00a0(\u00f6rne\u011fin sunitinib veya everolimus); bu ila\u00e7lar, t\u00fcm\u00f6r b\u00fcy\u00fcmesini ve yay\u0131lmas\u0131n\u0131 yava\u015flatmak i\u00e7in a\u011f\u0131z yoluyla al\u0131n\u0131r.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\"><b>Embolizasyon<\/b>: T\u00fcm\u00f6re kan ak\u0131\u015f\u0131n\u0131 azaltarak semptomlar\u0131 kontrol etmede kullan\u0131lan bir tekniktir. Bazen t\u00fcm\u00f6r h\u00fccrelerinin b\u00fcy\u00fcmesini \u00f6nlemek i\u00e7in kemoterapi veya radyasyon terapisi ile birle\u015ftirilerek kullan\u0131labilir.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\"><b>Radyofrekans ablasyonu<\/b>: Genel anestezi alt\u0131nda yap\u0131lan ve karaci\u011fer t\u00fcm\u00f6rlerini \u00e7\u0131karmak amac\u0131 ile \u0131s\u0131 iletmek i\u00e7in d\u00fc\u015f\u00fck elektrik ak\u0131m\u0131 kullanan bir prosed\u00fcrd\u00fcr.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\"><b>Di\u011fer<\/b>\u00a0<b>hedefe y\u00f6nelik radyon\u00fcklid tedaviler<\/b>: 131I-mIBG gibi radyon\u00fcklid tedavilerdir.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\">Bu tedaviler hekiminizin \u00f6nerisiyle birbiri ard\u0131na veya bir arada kullan\u0131labilir. T\u00fcm tedavi se\u00e7eneklerini tart\u0131\u015ft\u0131ktan sonra, herhangi bir tedaviyi almay\u0131 ya da almamay\u0131 tercih edebilirsiniz. Ayr\u0131ca hekiminiz bu t\u00fcr tedavilerin size yard\u0131mc\u0131 olamayaca\u011f\u0131n\u0131 d\u00fc\u015f\u00fcnebilir ve size palyatif bak\u0131m da \u00f6nerebilir. Bu sizi desteklemeye ve semptomlar\u0131n\u0131z\u0131 hafifletmeye yard\u0131mc\u0131 olur.<\/span><\/p>\r\n<h3 class=\"p1\"><span class=\"s1\"><b>Lutesyum-177 DODA-TATE Tedavisi G\u00fcvenli midir?<\/b><\/span><\/h3>\r\n<p class=\"p3\"><span class=\"s1\">Lu-177 DOTA-TATE tedavisi alan NET hastalar\u0131m\u0131z, di\u011fer kanser tedavileri ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, minimal ve daha az ciddi uzun s\u00fcreli yan etkiler ya\u015famaktad\u0131rlar.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\">Bu tedavide kullan\u0131lan radyasyon, direkt kanser h\u00fccrelerine zarar vermek ve onlar\u0131 yok etmek i\u00e7in tasarlanm\u0131\u015ft\u0131r. Lu-177 DOTA-TATE \u2018in b\u00fcy\u00fck k\u0131sm\u0131 t\u00fcm\u00f6r dokusuna gitti\u011finden<b>, sa\u011fl\u0131kl\u0131 dokulara zarar minimum d\u00fczeydedir.<\/b><\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\">Ancak radyasyon, b\u00f6brek ve kemik ili\u011fini etkileyebilece\u011finden, hastalar tedavi sonras\u0131 kan testleri ile takip edilirler.\u00a0<\/span><span class=\"s1\">Tedavide; tedaviye ve v\u00fccudun ald\u0131\u011f\u0131 radyasyon dozuna ba\u011fl\u0131 olmak \u00fczere, iki t\u00fcr yan etki g\u00f6r\u00fclebilir:<\/span><\/p>\r\n<p class=\"p11\"><span class=\"s1\"><b><i>1.Tedaviye Ba\u011fl\u0131 Muhtemel Yan Etkiler<\/i><\/b><\/span><\/p>\r\n<ul>\r\n<li class=\"p3\"><span class=\"s1\">Mide bulant\u0131s\u0131 hissedebilirsiniz; bu genellikle sadece tedavinin verildi\u011fi g\u00fcn olur. Bunu \u00f6nlemek i\u00e7in \u00f6nceden bulant\u0131 \u00f6nleyici ila\u00e7lar verilmektedir.<\/span><\/li>\r\n<li class=\"p3\"><span class=\"s1\">T\u00fcm\u00f6rdeki yang\u0131 (enflamasyon), \u00f6zellikle kemik, karaci\u011fer veya pankreas\u0131nda t\u00fcm\u00f6r bulunan hastalar\u0131m\u0131zda g\u00f6rebildi\u011fimiz, a\u011fr\u0131 art\u0131\u015f\u0131na neden olabilir. Bu durum, genellikle tedaviyi takip eden 72 saat i\u00e7inde ge\u00e7er. \u015eikayetleri azaltmaya yard\u0131mc\u0131 olmak i\u00e7in d\u00fc\u015f\u00fck doz steroid (deksametazon) kullanman\u0131z gerekecektir, bununla birlikte normal a\u011fr\u0131 kesici ila\u00e7lar\u0131n\u0131z\u0131 daha d\u00fczenli alman\u0131z\u0131 da \u00f6neririz.<\/span><\/li>\r\n<li class=\"p2\"><span class=\"s1\">K\u0131zarma, terleme, \u00e7arp\u0131nt\u0131 veya h\u0131r\u0131lt\u0131l\u0131 soluma gibi g\u00fcnl\u00fck semptomlar\u0131n\u0131z\u0131n yo\u011funlu\u011funda ge\u00e7ici bir art\u0131\u015fa ve mevcut ishal s\u0131kl\u0131\u011f\u0131n\u0131n artmas\u0131na neden olabilir. Bu durum genellikle 24-48 saat i\u00e7inde dengelenir, kulland\u0131\u011f\u0131n\u0131z antidiyareik ila\u00e7 miktar\u0131n\u0131 da art\u0131rman\u0131z gerekebilir.<\/span><\/li>\r\n<li class=\"p2\"><span class=\"s1\">Tedavinin her bir k\u00fcr\u00fc sonras\u0131ndaki birka\u00e7 hafta halsiz hissetmenizi sa\u011flayabilir.<\/span><\/li>\r\n<li class=\"p2\"><span class=\"s1\">Ge\u00e7ici sa\u00e7 seyrelmesi; baz\u0131 hastalar\u0131m\u0131zda g\u00f6r\u00fclebilecek bir durumdur ve Lu-177 DOTA-TATE tedavisi tamamland\u0131ktan sonra tekrar normale d\u00f6nmektedir.<\/span><\/li>\r\n<\/ul>\r\n<p class=\"p3\"><span class=\"s1\">Tabii ki kendinizi farkl\u0131 hissetmemeniz ve bu yan etkilerden herhangi birini ya\u015famaman\u0131z da m\u00fcmk\u00fcnd\u00fcr.<\/span><\/p>\r\n<p class=\"p11\"><span class=\"s1\"><b><i>2. Radyasyon Dozu \u0130le \u0130lgili Yan Etkiler<\/i><\/b><\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\">Her ne kadar sa\u011fl\u0131kl\u0131 normal h\u00fccreler, t\u00fcm\u00f6r dokusuyla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda \u00e7ok d\u00fc\u015f\u00fck miktarda Lu-177 DOTA-TATE tutulumu g\u00f6sterseler de radyasyonun yan etkileri bu h\u00fccrelere de zarar verebilir.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\">Lu-177 DOTA-TATE tedavisi v\u00fccudunuzun t\u00fcm\u00f6r d\u0131\u015f\u0131ndaki k\u0131s\u0131mlar\u0131n\u0131 da etkileyebilir. \u00d6zellikle kemik ili\u011finizi ve b\u00f6breklerinizi etkileyebilir. Bu, normalden daha halsiz hissetmenize veya tedaviden birka\u00e7 hafta sonra enfeksiyona daha yatk\u0131n olman\u0131za neden olabilir.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\">Kan say\u0131m\u0131n\u0131z\u0131 (kan h\u00fccreleri) kontrol etmek, b\u00f6breklerinizin ve karaci\u011ferinizin nas\u0131l \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 g\u00f6rmek i\u00e7in her tedavi k\u00fcr\u00fcnden sonra d\u00fczenli kan testleri yapt\u0131rman\u0131z gerekecektir. Sekonder miyelodisplastik sendrom ve l\u00f6semi geli\u015fimi ise \u00e7ok nadir olmakla birlikte bildirilmi\u015ftir.\u00a0<\/span><span class=\"s1\">Lu-177 DOTA-TATE tedavisinden sonra, yukar\u0131da listelenmemi\u015f olsalar bile, yeni veya beklenmedik sa\u011fl\u0131k sorunlar\u0131n\u0131z oldu\u011funda, hekiminize bildirmeniz \u00f6nemlidir.<\/span><\/p>\r\n<h3 class=\"p11\"><span class=\"s1\"><b><i>Lutesyum-177 DOTA-TATE ve Hamilelik<\/i><\/b><\/span><\/h3>\r\n<p class=\"p3\"><span class=\"s1\">Her Lu-177 DOTA-TATE tedavi k\u00fcr\u00fcne ba\u015flamadan \u00f6nce hamilelik ihtimalini d\u0131\u015flamak i\u00e7in do\u011furganl\u0131k ya\u015f\u0131ndaki t\u00fcm kad\u0131nlardan gebelik testi i\u00e7in idrar \u00f6rne\u011fi vermeleri istenir. Hem erkeklere hem de kad\u0131nlara, tedavileri s\u0131ras\u0131nda ve tedaviyi tamamlad\u0131ktan sonra en az alt\u0131 ay boyunca \u00e7ocuk yapmamalar\u0131\/gebe kalmamalar\u0131 tavsiye edilir. Bu s\u00fcre boyunca g\u00fcvenilir do\u011fum kontrol y\u00f6ntemleri kullan\u0131lmal\u0131d\u0131r. Daha ayr\u0131nt\u0131l\u0131 bilgi i\u00e7in hekiminize dan\u0131\u015fabilirsiniz.<\/span><\/p>\r\n<h3 class=\"p12\"><span class=\"s1\"><b>Lutesyum-177 DODA-TATE Tedavisi \u00d6ncesinde Neler Yapman\u0131z \u0130stenir?<\/b><\/span><\/h3>\r\n<p class=\"p3\"><span class=\"s1\">Her tedavi k\u00fcr\u00fc i\u00e7in birka\u00e7 g\u00fcnl\u00fck hastane ziyaretiniz olacakt\u0131r. Tedavi i\u00e7in hastanede yatman\u0131z gerekebilir. D\u00f6rt k\u00fcr tedavinin tamamlanmas\u0131 sekiz ila on ay s\u00fcrmektedir. Son tedavi k\u00fcr\u00fcn\u00fcz de tamamland\u0131ktan sonra kontrol randevunuz planlanacakt\u0131r. Bu s\u00fcre zarf\u0131nda, sizi takip eden sorumlu hekiminizle de temas halinde olmal\u0131s\u0131n\u0131z.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\">Her tedavi k\u00fcr\u00fcnden \u00f6nce kan testi yapt\u0131rman\u0131z ve fizik muayeneden ge\u00e7meniz istenecektir. Bu i\u015flemler, genel sa\u011fl\u0131\u011f\u0131n\u0131zla ilgili k\u0131sa bir sorgulamayla birlikte, tedaviye uygunlu\u011funuzu de\u011ferlendirmemize yard\u0131mc\u0131 olacakt\u0131r.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\">Kulland\u0131\u011f\u0131n\u0131z t\u00fcm ila\u00e7lar hakk\u0131nda (hekiminiz taraf\u0131ndan re\u00e7ete edilmedi\u011fi halde kulland\u0131klar\u0131n\u0131z da dahil) bizleri bilgilendirmelisiniz. E\u011fer oktreotid (Sandostatin LAR\u00ae) veya lanreotid enjeksiyonlar\u0131 ile tedavi g\u00f6r\u00fcyorsan\u0131z, son enjeksiyonunuzun tarihini de bilmemiz gerekir. Bu, Lu-177 DOTA-TATE tedavi k\u00fcr\u00fcn\u00fc, enjeksiyonunuzun hemen \u00f6ncesindeki g\u00fcnlerde verebilecek \u015fekilde planlayabilmemiz i\u00e7in \u00f6nemlidir. E\u011fer g\u00fcnl\u00fck oktreotid enjeksiyonu yap\u0131yorsan\u0131z, bunu ne zaman sonland\u0131rman\u0131z gerekti\u011fini size bildirece\u011fiz. Tedavi \u00f6ncesi randevunuz s\u0131ras\u0131nda aksi belirtilmedi ise tedavinizin yap\u0131laca\u011f\u0131 g\u00fcn yiyip i\u00e7ebilirsiniz ve di\u011fer t\u00fcm ila\u00e7lar\u0131n\u0131z\u0131 normal \u015fekilde alabilirsiniz.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\">Tedaviden sonra bir gece hastanede kalman\u0131z gerekiyorsa, ki\u015fisel malzemelerinize ihtiyac\u0131n\u0131z olacakt\u0131r.\u00a0<\/span><span class=\"s1\">Ziyaret\u00e7ilerin sizinle ge\u00e7irebilecekleri s\u00fcre, radyasyon nedeniyle k\u0131s\u0131tlanacakt\u0131r. Tedaviye ba\u015flamadan \u00f6nce size bu konuda bilgi verilecektir. Bununla birlikte 16 ya\u015f\u0131n alt\u0131ndaki \u00e7ocuklar ve hamile kad\u0131nlar yan\u0131n\u0131zda gelmemeli veya sizi ziyaret etmemelidir.<\/span><\/p>\r\n<h3 class=\"p13\"><span class=\"s1\"><b>Lutesyum-177 DOTA-TATE Tedavisi Nas\u0131l Uygulan\u0131r?<\/b><\/span><\/h3>\r\n<p class=\"p10\"><span class=\"s1\">Tedaviniz N\u00fckleer T\u0131p B\u00f6l\u00fcm\u00fcnde verilecektir ve t\u00fcm prosed\u00fcr\u00fcn tamamlanmas\u0131 yakla\u015f\u0131k be\u015f saat s\u00fcrmektedir.<\/span><\/p>\r\n<p class=\"p10\"><span class=\"s1\">Kolunuzdaki bir damara plastik bir kan\u00fcl (k\u00fc\u00e7\u00fck bir plastik t\u00fcp) yerle\u015ftirilecektir. Bu kan\u00fcl yoluyla ilk olarak bulant\u0131 hissetmenizi \u00f6nlemek i\u00e7in ila\u00e7, daha sonra b\u00f6breklerinizi radyoaktiviteden korumaya yard\u0131mc\u0131 olacak amino asit inf\u00fczyonu (damla \u015feklinde) verilecektir.<\/span><\/p>\r\n<p class=\"p10\"><span class=\"s1\">Yakla\u015f\u0131k bir saat sonra, Lu-177 DOTA-TATE uygulamas\u0131 i\u00e7in sonra amino asit inf\u00fczyonu kesilecektir. Lu-177 DOTA inf\u00fczyonu yakla\u015f\u0131k 30 dakikada tamamland\u0131ktan sonra, amino asit inf\u00fczyonuna tekrar ba\u015flanarak i\u015fleme \u00fc\u00e7 saat daha devam edilecektir. \u0130\u015flemin tamamlanmas\u0131ndan sonra kan\u00fcl \u00e7\u0131kar\u0131lacakt\u0131r.<\/span><\/p>\r\n<h3 class=\"p16\"><span class=\"s1\"><b>Lutesyum-177 DOTA-TATE<i>\u00a0<\/i>Sonras\u0131nda Neler Yap\u0131l\u0131r?<\/b><\/span><\/h3>\r\n<p class=\"p3\"><span class=\"s1\">Ertesi sabah, tedavi sonras\u0131 taramalar i\u00e7in sizi N\u00fckleer T\u0131p B\u00f6l\u00fcm\u00fc\u2019nde bekliyor olaca\u011f\u0131z. Bu taramalar, tedavinizin planland\u0131\u011f\u0131 \u015fekilde gitti\u011fini kontrol etmek amac\u0131yla yap\u0131lacakt\u0131r ve \u00e7ekimler bir-iki saat s\u00fcrebilir.<\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\">Taramalardan sonra, N\u00fckleer T\u0131p ekibimizden bir sa\u011fl\u0131k personelimiz radyasyon seviyenizi \u00f6l\u00e7ecek ve hastaneden ayr\u0131l\u0131rken izlemeniz gereken \u00f6nlemler hakk\u0131nda sizi bilgilendirecektir. Bu \u00f6nlemler, \u00e7evrenizdeki insanlar\u0131n alaca\u011f\u0131 radyasyon dozunu azaltmak i\u00e7in gereklidir. \u00d6l\u00e7\u00fcm sonras\u0131nda v\u00fccudunuzdaki radyasyon seviyesi yeterince d\u00fc\u015f\u00fck ise eve gidebilirsiniz.<\/span><\/p>\r\n<p class=\"p11\"><span class=\"s1\"><b><i>Hastaneden Ayr\u0131ld\u0131ktan Sonra<\/i><\/b><\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\">Size verilen radyasyon \u00f6nlemleri hakk\u0131ndaki tavsiyelere mutlaka uyunuz.\u00a0<\/span><span class=\"s1\">Her bir tedavi k\u00fcr\u00fc sonras\u0131nda; tedavinin kan h\u00fccreleriniz, b\u00f6brekleriniz ve karaci\u011feriniz \u00fczerindeki etkisini kontrol etmek i\u00e7in 8 ila 10 hafta boyunca, her 2 haftada bir kan testi yapt\u0131rman\u0131z istenecektir.<\/span><\/p>\r\n<p class=\"p11\"><span class=\"s1\"><b><i>\u0130\u015fe Yeniden Ba\u015flama<\/i><\/b><\/span><\/p>\r\n<p class=\"p3\"><span class=\"s1\">Ne zaman i\u015fe geri d\u00f6nece\u011finizin karar\u0131 verilirken, yapt\u0131\u011f\u0131n\u0131z i\u015fin t\u00fcr\u00fc dikkate al\u0131nacakt\u0131r. Bu konuda N\u00fckleer T\u0131p Hekiminiz sizinle g\u00f6r\u00fc\u015fecektir.<\/span><\/p>\r\n<p><a href=\"https:\/\/www.intheranostics.com\/iletisim\/\"><strong>Daha fazla bilgi i\u00e7in l\u00fctfen bizimle irtibata ge\u00e7iniz.<\/strong><\/a><\/p>\r\n[\/et_pb_text][et_pb_accordion disabled_on=\"on|on|on\" _builder_version=\"%224.4.8%22\" disabled=\"on\"][et_pb_accordion_item title=\"%22TANI\" open=\"on\" open_toggle_text_color=\"%22#0ca7c5%22\" _builder_version=\"%224.4.8%22\" toggle_font=\"%22|700|||||||%22\" toggle_font_size=\"%2218px%22\"]<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT Nedir, T\u00fcm\u00f6r Oda\u011f\u0131n\u0131 Nas\u0131l G\u00f6sterir?<\/b><\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b><span style=\"float: none;background-color: #ffffff;color: #666666;font-family: 'Quicksand',Helvetica,Arial,Lucida,sans-serif;font-size: 100%;font-style: normal;font-variant: normal;font-weight: 500;letter-spacing: normal;text-align: left;text-decoration: none;text-indent: 0px;text-transform: none\">Teranostik t\u0131p d\u00fcnyas\u0131nda yeni geli\u015fmekte olan bir aland\u0131r. T\u00fcm\u00f6re \u00f6zg\u00fcl bir ila\u00e7 ile g\u00f6r\u00fcnt\u00fcleme yaparak saptanan t\u00fcm\u00f6r ve metastazlar\u0131n\u0131n, nereye gidece\u011fi, ne kadar gidece\u011fi ve hastal\u0131kl\u0131 dokuyu etkileme g\u00fcc\u00fc \u00f6nceden bilinen yine \u00f6zg\u00fcl bir ila\u00e7 ile tedavi edilebildi\u011fi bir yakla\u015f\u0131md\u0131r. Bu yakla\u015f\u0131m, geleneksel t\u0131ptan ki\u015fiye \u00f6zg\u00fc \u00e7a\u011fda\u015f t\u0131p uygulamalar\u0131na ge\u00e7i\u015f yap\u0131lmas\u0131n\u0131 sa\u011flamaktad\u0131r.<\/span><\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Prostat kanserinden \u00f6l\u00fcmler genellikle kemik metastaz\u0131 ve komplikasyonlar\u0131ndan kaynaklanmaktad\u0131r. Prostat kanseri kemik metastazlar\u0131\u00a0Flor-18 NaF (<\/span><span class=\"s2\"><sup>18<\/sup><\/span><span class=\"s1\">F-NaF) PET\/BT ile y\u00fcksek duyarl\u0131l\u0131kla g\u00f6r\u00fcnt\u00fclenebilmekte ve Radyum-223 ile bu t\u00fcm\u00f6ral dokular\u0131n \u00f6zg\u00fcl ve hedefe y\u00f6nelik tedavisi yap\u0131labilmektedir. Bu, teranostik uygulamalar i\u00e7in olduk\u00e7a ba\u015far\u0131l\u0131 bir \u00f6rnektir.<\/span><\/p>\r\n<p class=\"p4\"><span class=\"s1\">Hastal\u0131\u011f\u0131n\u0131z\u0131 takip eden hekiminiz, kemik metastazlar\u0131n\u0131n tan\u0131s\u0131 amac\u0131yla size bu tetkiki \u00f6nerebilir.\u00a0F-18 NaF PET\/BT; kemik metastazlar\u0131n\u0131n yeri ve yayg\u0131nl\u0131\u011f\u0131n\u0131 do\u011fru bir \u015fekilde g\u00f6sterirken a\u011fr\u0131l\u0131 kemik metastazlar\u0131nda hedefe y\u00f6nelik ba\u015far\u0131l\u0131 bir tedavi se\u00e7ene\u011fi olan Radyum-223 tedavisinin kullan\u0131m\u0131n\u0131 da m\u00fcmk\u00fcn k\u0131lar.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT\u2019nin \u00dcst\u00fcn Yanlar\u0131 Nelerdir?<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">F-18 NaF PET\/BT, kemik g\u00f6r\u00fcnt\u00fcleme maddesi olarak ideal \u00f6zelliklere sahiptir ve 45-60 dakika gibi k\u0131sa bir s\u00fcre i\u00e7inde \u00fcst\u00fcn kalitede g\u00f6r\u00fcnt\u00fcler \u00fcretir.\u00a0Ba\u015fta kemik metastaz\u0131 ara\u015ft\u0131r\u0131lan hastalar olmak \u00fczere bir\u00e7ok hasta i\u00e7in,\u00a0F-18 NaF PET\/BT, geleneksel kemik sintigrafisine g\u00f6re \u00e7ok daha ba\u015far\u0131l\u0131 sonu\u00e7lar\u0131 ile ideal bir alternatiftir.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT Kimlere Uygulan\u0131r?<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Hastal\u0131\u011f\u0131n\u0131z\u0131 takip eden hekiminiz sizden\u00a0F-18 NaF PET\/BT taramas\u0131n\u0131 \u015fu ama\u00e7lar i\u00e7in isteyebilir:<\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"p4\"><span class=\"s1\">Kemik metastazlar\u0131n\u0131n belirlenmesi<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">Hastal\u0131\u011f\u0131n yayg\u0131nl\u0131\u011f\u0131n\u0131n do\u011fru belirlenmesi<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">Malign kemik lezyonlar\u0131n\u0131n yerinin belirlenmesi<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">Kemik a\u011fr\u0131lar\u0131n\u0131n sa\u011falt\u0131m\u0131 i\u00e7in Radyum-223 tedavisinin uygun olup olmad\u0131\u011f\u0131n\u0131n belirlenmesi<\/span><\/li>\r\n \t<li class=\"p4\">Tedavi yan\u0131t\u0131n\u0131n de\u011ferlendirilmesi<\/li>\r\n<\/ul>\r\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT G\u00fcvenli midir?<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">F-18 NaF bilinen yan etkisi olmayan g\u00fcvenli bir radyoaktif maddedir. Bu i\u015flemde al\u0131nan radyasyon dozu azd\u0131r ve g\u00fcn sonunda v\u00fccudunuzdan temizlenir. N\u00fckleer T\u0131p klini\u011finden ayr\u0131lman\u0131z birka\u00e7 saat s\u00fcrmektedir. PET\/BT taramas\u0131n\u0131 izleyen 6 saat boyunca ba\u015fkalar\u0131yla (\u00f6zellikle \u00e7ocuklar ve hamile kad\u0131nlar) temas\u0131n\u0131z\u0131 en aza indirmenizi \u00f6nermekteyiz.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT \u00d6ncesi Haz\u0131rl\u0131k<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">F-18 NaF PET\/BT g\u00f6r\u00fcnt\u00fclemesi \u00f6ncesinde N\u00fckleer T\u0131p b\u00f6l\u00fcm\u00fcne iletmek \u00fczere, hastal\u0131\u011f\u0131n\u0131za y\u00f6nelik baz\u0131 tetkik ve bilgileri yan\u0131n\u0131zda bulundurman\u0131z istenecektir:<\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"p4\"><span class=\"s1\">Hekim istem formu<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">Prostat kanseri hikayeniz (\u00f6rn. PSA, patoloji sonu\u00e7lar\u0131)<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">\u00d6nceki onkolojik tedavilerinizin tipi ve tarihi (\u00f6rn. kemoterapi ve\/veya radyoterapi)<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">\u00d6nceki k\u0131r\u0131klar\u0131n\u0131z veya yak\u0131n tarihli travma hikayeniz (yeri ve tarihi)<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">\u00d6nceki ortopedik cerrahi giri\u015fimleriniz (m\u00fcdahale tarihi, tipi ve yeri)<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">\u00d6nceki enfeksiyon ve yeri<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">\u0130drar yolu ile ilgili ge\u00e7irilmi\u015f ameliyatlar<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">Her bir kemik a\u011fr\u0131n\u0131z\u0131n yeri<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">Di\u011fer g\u00f6r\u00fcnt\u00fclemeler ve raporlar\u0131 (\u00f6zellikle kemik sintigrafisi, BT veya MRI)<\/span><\/li>\r\n<\/ul>\r\n<p class=\"p2\"><span class=\"s1\">F-18 NaF PET\/BT i\u015flemi i\u00e7in a\u00e7 olman\u0131za gerek yoktur. \u0130la\u00e7lar\u0131n\u0131z\u0131 her zamanki gibi alabilirsiniz. <\/span><span class=\"s1\">B\u00f6brekten at\u0131l\u0131m\u0131 art\u0131rmak, al\u0131nan radyasyon dozunu azaltmak ve en iyi g\u00f6r\u00fcnt\u00fc kalitesine ula\u015fmak i\u00e7in,\u00a0F-18 NaF enjeksiyonu \u00f6ncesinde ve sonras\u0131nda en az iki\u015fer bardak su i\u00e7melisiniz. Tetkik sonras\u0131nda g\u00fcn\u00fcn geri kalan\u0131nda da su i\u00e7meye devam etmeniz faydal\u0131 olacakt\u0131r.\u00a0\u0130\u015flem s\u0131ras\u0131nda g\u00f6r\u00fcnt\u00fc bozulmalar\u0131n\u0131 \u00f6nlemek i\u00e7in t\u00fcm metal e\u015fyalar\/tak\u0131lar\/protezler \u00e7\u0131kar\u0131lmal\u0131d\u0131r.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT Nas\u0131l Uygulan\u0131r?<\/b><\/span><\/p>\r\n<p class=\"p4\"><span class=\"s1\">Az miktarda (1.5-3.7 Mbq\/Kg (0.04-0.1 mCi\/Kg) dozunda) F-18-NaF, g\u00f6r\u00fcnt\u00fcleme i\u015fleminden yakla\u015f\u0131k 30-60 dakika \u00f6nce, kol ya da el s\u0131rt\u0131n\u0131za yerle\u015ftirdi\u011fimiz damar yolundan uygulanacakt\u0131r.\u00a0<\/span><span class=\"s1\">F-18 NaF PET\/BT g\u00f6r\u00fcnt\u00fclemesinden hemen \u00f6nce mesanenizi bo\u015faltman\u0131z gerekmektedir.<\/span><\/p>\r\n<p class=\"p4\"><span class=\"s1\">PET\/BT g\u00f6r\u00fcnt\u00fclemesi boyunca (yakla\u015f\u0131k 20-25 dk.), v\u00fccut g\u00f6r\u00fcnt\u00fclerinin s\u00fcrekli kaydedildi\u011fi, her iki ucu a\u00e7\u0131k, geni\u015f halka \u015feklindeki bir cihazda, \u00f6zel \u00e7ekim yata\u011f\u0131 \u00fczerinde uzanman\u0131z istenecektir. \u0130\u015flemin tek zahmetli yan\u0131; bu s\u00fcre zarf\u0131nda hareketsiz kalman\u0131zd\u0131r. \u0130htiyac\u0131n\u0131z halinde, g\u00f6r\u00fcnt\u00fcleme \u00f6ncesi, beraberinizde getirdi\u011finiz a\u011fr\u0131 kesicinizi kullanabilirsiniz.<\/span><\/p>\r\n<p class=\"p4\"><span class=\"s1\">\u0130htiya\u00e7 duyulursa uzmanlar\u0131m\u0131z ek g\u00f6r\u00fcnt\u00fc alabilir. Ek g\u00f6r\u00fcnt\u00fcleme i\u015flemi yakla\u015f\u0131k 10-15 dakika s\u00fcrmektedir. <\/span><span class=\"s1\">N\u00fckleer T\u0131p klini\u011findeki i\u015flemlerin tamamlanmas\u0131 birka\u00e7 saati bulabilir. <\/span><span class=\"s1\">Kolunuzdaki damar yolu, g\u00f6r\u00fcnt\u00fclemeniz tamamland\u0131ktan ve t\u00fcm g\u00f6r\u00fcnt\u00fcleriniz kontrol edildikten sonra \u00e7\u0131kart\u0131lacakt\u0131r. Sa\u011fl\u0131k personelimizin onay vermesiyle, N\u00fckleer T\u0131p b\u00f6l\u00fcm\u00fcnden art\u0131k g\u00fcvenle ayr\u0131labilirsiniz.<\/span><\/p>\r\n<p class=\"p4\"><span class=\"s1\">\u0130la\u00e7 verildikten sonra ilk 6 saat k\u00fc\u00e7\u00fck \u00e7ocuklarla ve hamile kad\u0131nlarla temastan ka\u00e7\u0131nman\u0131z gerekti\u011fini l\u00fctfen unutmay\u0131n\u0131z. G\u00f6r\u00fcnt\u00fcleriniz N\u00fckleer T\u0131p Uzmanlar\u0131m\u0131z taraf\u0131ndan belirtilen s\u00fcrede de\u011ferlendirilerek rapor edilecektir.<\/span><\/p>\r\n[\/et_pb_accordion_item][et_pb_accordion_item title=\"TEDAV\u0130 H\u0130ZMETLER\u0130 - RADYUM-223 TEDAV\u0130S\u0130\" open_toggle_text_color=\"#0ca7c5\" _builder_version=\"4.4.8\" toggle_font=\"|700|||||||\" toggle_font_size=\"18px\" open=\"off\"]<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi Nedir?<\/b><\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\">Teranostik t\u0131p d\u00fcnyas\u0131nda yeni geli\u015fmekte olan bir aland\u0131r. T\u00fcm\u00f6re \u00f6zg\u00fcl bir ila\u00e7 ile g\u00f6r\u00fcnt\u00fcleme yaparak saptanan t\u00fcm\u00f6r ve metastazlar\u0131n\u0131n, nereye gidece\u011fi-ne kadar gidece\u011fi ve hastal\u0131kl\u0131 dokuyu etkileme g\u00fcc\u00fc \u00f6nceden bilinen yine \u00f6zg\u00fcl bir ila\u00e7 ile tedavi edilebildi\u011fi bir yakla\u015f\u0131md\u0131r. Bu yakla\u015f\u0131m, geleneksel t\u0131ptan ki\u015fiye \u00f6zg\u00fc \u00e7a\u011fda\u015f t\u0131p uygulamalar\u0131na ge\u00e7i\u015f yap\u0131lmas\u0131n\u0131 sa\u011flamaktad\u0131r.<\/span><\/p>\r\n<p class=\"p2\">Prostat kanseri<strong>\u00a0<\/strong>v\u00fccudun di\u011fer b\u00f6lgelerine yay\u0131ld\u0131\u011f\u0131nda, s\u0131kl\u0131kla kemiklerde yerle\u015fmektedir. Kemik metastaz\u0131 a\u011fr\u0131 d\u0131\u015f\u0131nda, k\u0131r\u0131k, omurilik s\u0131k\u0131\u015fmas\u0131 veya hayat\u0131 tehdit edebilen y\u00fcksek kan kalsiyum seviyeleri gibi ba\u015fka sorunlara da neden olabilir. Kanser kemiklere ula\u015ft\u0131\u011f\u0131nda, a\u011fr\u0131y\u0131 ve di\u011fer komplikasyonlar\u0131 kontrol etmek veya hafifletmek tedavinin \u00e7ok \u00f6nemli bir par\u00e7as\u0131d\u0131r. Hormon tedavisi, kemoterapi ve a\u015f\u0131lar gibi tedaviler buna yard\u0131mc\u0131 olabilir. Ancak uygun hastalarda, \u00f6zellikle kemik metastaz\u0131n\u0131 hedef alan ve alfa \u0131\u015f\u0131mas\u0131 yapan Radyum-223 tedavisi ile bir yandan semptomlar kontrol alt\u0131na al\u0131n\u0131rken bir yandan da sa\u011f kal\u0131m\u0131 art\u0131r\u0131c\u0131 etki sa\u011flanabilmektedir.<\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Nas\u0131l Tedavi Eder?<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Radyum-223, kemik metastazlar\u0131na se\u00e7ici olarak ba\u011flanan ve \u00e7ok k\u0131sa menzilli y\u00fcksek enerjili par\u00e7ac\u0131klar\u0131 (<100 \u03bcm) yayan, radyoaktif bir elementtir. Radyum-223 diklor\u00fcr molek\u00fcl\u00fc, kalsiyumu taklit ederek kemik metastazlar\u0131na ba\u011flan\u0131r ve ard\u0131ndan y\u00fcksek enerjili alfa par\u00e7ac\u0131\u011f\u0131na ait radyasyon, DNA k\u0131r\u0131klar\u0131na neden olarak t\u00fcm\u00f6r h\u00fccrelerini \u00f6ld\u00fcr\u00fcr. Alfa par\u00e7ac\u0131klar\u0131n\u0131n k\u0131sa olan menzili, kom\u015fu sa\u011fl\u0131kl\u0131 doku ve \u00f6zellikle kemik ili\u011fi \u00fczerindeki zararl\u0131 etkinin de en az d\u00fczeyde kalmas\u0131 anlam\u0131na gelmektedir.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Sa\u011f kal\u0131m\u0131 uzatt\u0131\u011f\u0131 bilinen kemi\u011fe \u00f6zg\u00fc tek ila\u00e7, radyoaktif alfa par\u00e7ac\u0131\u011f\u0131 yayarak tedavi edici etkisini g\u00f6steren Radyum-223't\u00fcr. Bilimsel \u00e7al\u0131\u015fmalar ile Radyum-223 tedavisinin ortalama ya\u015fam s\u00fcresini uzatt\u0131\u011f\u0131 g\u00f6sterilmi\u015ftir. Buna ek olarak a\u011fr\u0131da ve ya\u015fam kalitesinde iyile\u015fmeyi sa\u011flamaktad\u0131r. T\u00fcm bu faydalar\u0131n\u0131n yan\u0131nda kan de\u011ferlerinde ge\u00e7ici d\u00fc\u015fme ve ishal d\u0131\u015f\u0131nda Radyum-223 tedavisi ile ili\u015fkili yan etkiler olduk\u00e7a hafif d\u00fczeylerde izlenmi\u015ftir.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi Kimlere Uygulan\u0131r?<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisi \u00e7ok spesifik bir tedavi t\u00fcr\u00fcd\u00fcr, bu nedenle sadece kemiklere yay\u0131lm\u0131\u015f ve a\u011fr\u0131 \u015fikayeti olan prostat kanserli hastalarda, takip eden hekimleri taraf\u0131ndan uygun g\u00f6r\u00fclmesi durumunda uygulanabilir.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisi, kemi\u011fe yay\u0131lm\u0131\u015f kanserin s\u0131kl\u0131kla neden oldu\u011fu a\u011fr\u0131y\u0131 hafifletebilir. Bu tedavinin uygulanmas\u0131na karar verildi\u011finde, tedavi \u00f6ncesinde, t\u00fcm v\u00fccut kemik taramas\u0131 (\u00f6rn. F-NaF PET\/BT, kemik sintigrafisi) yap\u0131lmaktad\u0131r. Bu, Radyum-223'\u00fcn tedavi s\u0131ras\u0131nda do\u011fru alanlar\u0131 hedefledi\u011finden emin olunmas\u0131n\u0131 sa\u011flayacakt\u0131r.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi G\u00fcvenli midir?<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisinde kullan\u0131lan alfa radyasyonu \u00e7ok y\u00fcksek bir enerji seviyesine sahiptir. Bununla birlikte alfa radyasyon, do\u011fas\u0131 gere\u011fi sadece \u00e7ok k\u0131sa mesafelere (iki ila on h\u00fccre mesafesinde) seyahat eder ve bu da radyasyonun yok edici etkisinin sa\u011fl\u0131kl\u0131 h\u00fccrelerde de\u011fil, kemikteki kanser h\u00fccrelerinde olu\u015fmas\u0131n\u0131 sa\u011flamaktad\u0131r. Sa\u011fl\u0131kl\u0131 h\u00fccrelerce al\u0131nan minimal radyasyon dozu, Radium-223 tedavisi ile ili\u015fkili yan etkilerin de ihmal edilebilir d\u00fczeyde oldu\u011fu anlam\u0131na gelir ve \u00fcretilen kan h\u00fccrelerinin say\u0131s\u0131nda ge\u00e7ici bir azalma ve nadiren bulant\u0131, kusma ve ishal, tedavi olan hastalar\u0131m\u0131zda g\u00f6r\u00fclebilmektedir.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi \u00d6ncesi Haz\u0131rl\u0131k \u00a0<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Klini\u011fe ilk ba\u015fvurunuzda, a\u015fa\u011f\u0131da listelenen bilgi ve belgeleri beraberinizde getirmeniz \u00f6nemlidir. Hasta bilgilerinizin dijital ortamda haz\u0131rlanmas\u0131 (DICOM, JPEG, PNG, PDF, Microsoft Word (.doc, .docx, vb.)), e-posta ile h\u0131zl\u0131 ve kolayca payla\u015f\u0131lmas\u0131na imkan tan\u0131yacak ve hastal\u0131\u011f\u0131n\u0131z\u0131n de\u011ferlendirilmesini b\u00fcy\u00fck oranda kolayla\u015ft\u0131racakt\u0131r:<\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"p2\"><span class=\"s1\">Sizin ve sizi takip eden hekiminizin ileti\u015fim bilgileri (ev\/i\u015f\/cep telefon numaras\u0131, e-posta adresi)<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">En g\u00fcncel hekim raporlar\u0131<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Patoloji raporlar\u0131<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Kan testleri<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">T\u00fcm v\u00fccut kemik sintigrafisi, BT, MR ve 68Ga-PSMA PET\/BT, 18F-FDG PET\/BT raporlar\u0131 ve orijinal film\/CD\/DVD'leri<\/span><\/li>\r\n<\/ul>\r\n<p class=\"p2\"><span class=\"s1\">N\u00fckleer T\u0131p Hekiminiz, bu tedavi \u00f6ncesinde ihtiya\u00e7 duyulmas\u0131 halinde, tedaviye uygunlu\u011funuzu de\u011ferlendirmek amac\u0131yla 18F-NaF PET\/BT veya t\u00fcm v\u00fccut kemik sintigrafisi g\u00f6r\u00fcnt\u00fclemeleri ile kemik erimesi varl\u0131\u011f\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 i\u00e7in kemik mineral yo\u011funlu\u011fu \u00f6l\u00e7\u00fcm\u00fc isteyebilir.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Ayr\u0131ca a\u015fa\u011f\u0131daki kan testlerini yapt\u0131rman\u0131z istenecektir. Bu testlerin, tedavi s\u0131ras\u0131ndaki durumunuzu g\u00f6stermesi beklendi\u011finden, tedaviden en ge\u00e7 2 hafta \u00f6nce yap\u0131lm\u0131\u015f olmas\u0131 gerekmektedir. Bu testler tedaviye ba\u015flarken ve her tedavi k\u00fcr\u00fcnden \u00f6nce yap\u0131lacakt\u0131r.<\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"p2\"><span class=\"s1\">PSA<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Tam kan say\u0131m\u0131<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Alkalen fosfataz<\/span><\/li>\r\n<\/ul>\r\n<p class=\"p2\"><span class=\"s1\">Hekiminiz, gerekti\u011finde ek kan testleri de isteyebilir. <\/span><span class=\"s1\">Karaci\u011fer ve b\u00f6brek yetmezli\u011fi olan hastalar\u0131m\u0131zda, Radyum-223 tedavisi herhangi bir doz ayarlamas\u0131na gitmeden uygulanabilir.<\/span><span class=\"s1\">Kemik k\u0131r\u0131\u011f\u0131 ya da omurilik bas\u0131s\u0131 olan hastalar\u0131m\u0131zda ise \u00f6ncelikle bu sorunlar\u0131n d\u00fczeltilmesi istenecektir.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Kemoterapi tedavisi ald\u0131ysan\u0131z en son k\u00fcr\u00fcn \u00fczerinden en az 4 hafta ge\u00e7ti\u011finden emin olman\u0131z gerekmektedir.<\/span><span class=\"s1\">Tedavi s\u0131ras\u0131nda evden getirdi\u011finiz kendi giysilerinizi giyece\u011finiz i\u00e7in rahat ve geni\u015f k\u0131yafetler tercih etmenizi \u00f6neririz. Tedaviniz ve birlikte yap\u0131lan testler i\u00e7in kolunuza veya elinizin s\u0131rt\u0131na yerle\u015ftirilen damar yolu kullan\u0131laca\u011f\u0131ndan, k\u0131sa kollu ya da geni\u015f kollu giysileri bulundurman\u0131z yararl\u0131 olacakt\u0131r.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Radyum-223 ba\u011f\u0131rsaktan at\u0131ld\u0131\u011f\u0131 i\u00e7in \u201c\u00fclseratif kolit\u201d ve \u201cCrohn hastal\u0131\u011f\u0131\u201d gibi enflamatuar ba\u011f\u0131rsak hastal\u0131\u011f\u0131 olan ya da ba\u011f\u0131rsak t\u0131kan\u0131kl\u0131\u011f\u0131 hikayesi bulunan hastalar\u0131m\u0131zda ek destekleyici \u00f6nlemler almam\u0131z gerekebilir.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi Nas\u0131l Uygulan\u0131r?<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Standard Radyum-223 tedavisi; d\u00f6rt haftal\u0131k aral\u0131klarla, toplam alt\u0131 tedavi k\u00fcr\u00fcnden (6 adet, birer dakikal\u0131k enjeksiyon) olu\u015fmaktad\u0131r. <\/span><span class=\"s1\">Sizin i\u00e7in \u00fcretilmi\u015f, kullan\u0131ma haz\u0131r Radyum-223 diklor\u00fcr \u00e7\u00f6zeltisi, N\u00fckleer T\u0131p Klini\u011finde, yerle\u015ftirdi\u011fimiz periferik damar yoluyla enjekte edilecektir.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Radyum-223 uygulamadan \u00f6nce, damar yolunuzun a\u00e7\u0131kl\u0131\u011f\u0131, en az 10 ml serum fizyolojik ile y\u0131kanarak kontrol edilecek ve Radyum-223 yakla\u015f\u0131k 1 dakika boyunca yava\u015f enjeksiyon \u015feklinde uygulanacak, sonras\u0131nda damar yolunuz yine en az 10 ml serum fizyolojik ile y\u0131kanacakt\u0131r. Bu i\u015flem s\u0131ras\u0131nda a\u011fr\u0131 hissedilmemektedir.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Enjeksiyondan sonra Radyum-223 diklor\u00fcr h\u0131zla kandan temizlenecek ve \u00f6ncelikle kemik ve kemik metastazlar\u0131nda tutulacak veya ba\u011f\u0131rsa\u011fa at\u0131lacakt\u0131r.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Olas\u0131 Yan Etkiler ve Talimatlar<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisi uygulanan hastalar\u0131m\u0131zda g\u00f6r\u00fclebilecek en yayg\u0131n yan etkiler (\u2265% 10) bulant\u0131, kusma ve ishaldir. Ayr\u0131ca kan h\u00fccre say\u0131s\u0131nda ge\u00e7ici d\u00fc\u015fmeler g\u00f6r\u00fclebilmektedir.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Tedavi alan hastalar\u0131m\u0131z\u0131n a\u015fa\u011f\u0131daki talimatlara uymalar\u0131 \u00f6nemlidir:\u00a0\u00a0<\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"p2\"><span class=\"s1\">Size belirtilen tarihlerde kan say\u0131m\u0131n\u0131z\u0131 yapt\u0131r\u0131n\u0131z. Kanama veya enfeksiyon belirtilerini hekiminize iletiniz.<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">A\u011f\u0131zdan su al\u0131m\u0131n\u0131z iyi d\u00fczeyde olmal\u0131d\u0131r, v\u00fccut su d\u00fczeyi ve idrar \u00e7\u0131k\u0131\u015f\u0131n\u0131z\u0131 takip ediniz.<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">V\u00fccudunuzun susuz kalmas\u0131 veya b\u00f6brek yetmezli\u011fi belirtileri geli\u015firse hekiminize bildiriniz.<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Tedavi sonras\u0131 di\u011fer insanlarla temas konusunda herhangi bir k\u0131s\u0131tlaman\u0131z yoktur.<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Radyum-223 al\u0131rken ve son enjeksiyondan sonra en az 1 hafta boyunca iyi hijyen uygulamalar\u0131na dikkat ediniz.\r\n<\/span><span class=\"s1\">- Klozeti oturarak kullan\u0131n\u0131z ve her kullan\u0131mdan sonra sifonu en az 2 kez \u00e7ekiniz.\r\n<\/span><span class=\"s1\">- \u0130drar ve d\u0131\u015fk\u0131 ile kirlenmi\u015f giysilerinizi derhal ve di\u011fer k\u0131yafetlerden ayr\u0131 olarak y\u0131kay\u0131n\u0131z.<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Bak\u0131c\u0131lar\u0131n\u0131z, bula\u015f\u0131 \u00f6nlemek i\u00e7in v\u00fccut s\u0131v\u0131lar\u0131n\u0131z\u0131 tutarken eldiven kullanmal\u0131, sonras\u0131nda ellerini y\u0131kamal\u0131d\u0131r.<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Cinsel olarak aktif olan hastalar\u0131m\u0131z prezervatif kullanmal\u0131 ve \u00fcreme potansiyeli olan kad\u0131n partnerleri de tedavi s\u0131ras\u0131nda ve tedavinin tamamlanmas\u0131n\u0131 takip eden 6 ay boyunca etkili bir do\u011fum kontrol y\u00f6ntemi uygulamal\u0131d\u0131r.<\/span><\/li>\r\n<\/ul>\r\n<p class=\"p2\"><span class=\"s1\"><i>Daha fazla bilgi i\u00e7in l\u00fctfen bizimle irtibata ge\u00e7iniz.<\/i><\/span><\/p>\r\n[\/et_pb_accordion_item][\/et_pb_accordion][et_pb_code _builder_version=\"4.4.8\"][\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section]","_et_gb_content_width":"","footnotes":""},"class_list":["post-2340","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lutetium-177 DOTA-TATE - intheranostics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.intheranostics.com\/en\/lutetium-177-dota-tate\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lutetium-177 DOTA-TATE - intheranostics\" \/>\n<meta property=\"og:description\" content=\"[et_pb_section fb_built=&#8221;1&#8243; 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