{"id":2333,"date":"2020-10-01T15:39:19","date_gmt":"2020-10-01T12:39:19","guid":{"rendered":"https:\/\/www.intheranostics.com\/?page_id=2333"},"modified":"2020-10-01T16:02:51","modified_gmt":"2020-10-01T13:02:51","slug":"radium-223-therapy","status":"publish","type":"page","link":"https:\/\/www.intheranostics.com\/en\/radium-223-therapy\/","title":{"rendered":"Radium-223 Therapy"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.4.8&#8243; background_color=&#8221;rgba(0,0,0,0)&#8221; background_image=&#8221;https:\/\/www.intheranostics.com\/wp-content\/uploads\/2020\/06\/metastatik_prostat_kanseri.jpg&#8221; custom_padding=&#8221;100px||100px||false|false&#8221; locked=&#8221;off&#8221;][et_pb_fullwidth_header title=&#8221;Radium-223 Therapy&#8221; text_orientation=&#8221;center&#8221; content_max_width_last_edited=&#8221;off|desktop&#8221; _builder_version=&#8221;4.4.8&#8243; title_font_size=&#8221;50px&#8221; content_font_size=&#8221;41px&#8221; subhead_font=&#8221;|700|||||||&#8221; subhead_font_size=&#8221;38px&#8221; subhead_line_height=&#8221;1.1em&#8221; background_enable_color=&#8221;off&#8221; background_enable_image=&#8221;off&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221;][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.4.8&#8243; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221;][et_pb_row _builder_version=&#8221;4.4.8&#8243; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.4.8&#8243;][et_pb_divider divider_weight=&#8221;0px&#8221; _builder_version=&#8221;4.4.8&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_start=&#8221;#8dd2e1&#8243; background_color_gradient_end=&#8221;#23afca&#8221; background_color_gradient_direction=&#8221;90deg&#8221; width=&#8221;50%&#8221; module_alignment=&#8221;center&#8221; height=&#8221;10px&#8221;][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; _builder_version=&#8221;4.4.8&#8243;][et_pb_row admin_label=&#8221;row&#8221; _builder_version=&#8221;4.4.8&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.4.8&#8243; hover_enabled=&#8221;0&#8243;]<\/p>\n<h2>What is Radium-223 Therapy?<\/h2>\n<p>Theranostics is a recently developing field of the medicine. This approach takes body images using a tumor-specific agent to locate the tumor and its metastasis and their potential future locations and it also uses a specific agent with pre-determined therapeutic efficiency for the diseased tissue. This approach enables switching from traditional medicine to contemporary personalized medical procedures.<br \/>\nIn Theranostics practices, metastases can be diagnosed and treated with certain agents. For prostate cancer, F-18 NaF PET\/CT allows visualization of bone metastases with high sensitivity, while specific and targeted therapies of tumor tissues can be carried out with Radium-223. This is a rather successful example of theranostic procedures.<br \/>\nContrary to many other types of cancer, most of deaths related to prostate cancer are caused by bone metastasis and complications.<br \/>\nRadium-223 therapy is a treatment modality that can be used upon recommendation of a primary physician for patients with prostate cancer that spread or metastasized to bones. The goal is to damage cancerous cells in bones and cause tumors to shrink and even completely disappear. It is also used to manage bone pain secondary to cancer.\n<\/p>\n<h3>How is Radium-223 Used in Treatment?<\/h3>\n<p>Radium-223 is a radioactive element that selectively binds to bone metastases and radiates very short-range and high-energy alpha particles (< 100 \u03bcm). Radium-223 dichloride binds to bone metastases by mimicking calcium and then the radiation emitted by high-energy alpha particles kills tumor cells that cause DNA fragmentation. The short-range of alpha particles helps to minimize damage to adjacent healthy tissue and especially to bone marrow.\nRadium-223 with therapeutic effect based on emission of radioactive alpha particles is the only bone-specific drug that is known to prolong survival. Scientific studies have demonstrated that Radium-223 therapy prolongs average life expectancy. In addition, it helps with pain management and improves the quality of life. Besides all aforementioned advantages, side effects of Radium-223 therapy are very mild, except for temporary decrease in blood count and diarrhea.\n<\/p>\n<h3>Who are the Candidates for Radium-223 Therapy?<\/h3>\n<p>Radium-223 therapy is a very specific treatment method and therefore, it may be employed if deemed viable by a primary physician on patients with prostate cancer with only bone metastasis and pain.<br \/>\nRadium-223 therapy may alleviate pain, which is common in cancers that spread to bones. When the therapy is decided, a whole body bone scan (e.g. F-NaF PET\/CT, bone scan) is performed prior to treatment. This will allow making sure that correct areas are targeted in Radium-223 therapy.\n<\/p>\n<h3>Is Radium-223 Therapy Safe?<\/h3>\n<p>Alpha radiation, which is used for Radium-223 therapy, has a very high energy level. However, alpha radiation travels very short distances (at a range of two to ten cells) due to its nature, which fact helps to impose destructive effect of radiation on cancer cells in bones and unhealthy cells. Minimum radiation exposure of healthy cells makes side effects of Radium-223 therapy negligible, and temporary decrease in blood cell count and rare cases of nausea and diarrhea may be observed.<\/p>\n<h3>Preparation before Radium-223 Therapy<\/h3>\n<p>It is imperative that you bring all the information and documents listed below upon your visit to the clinic. Information presented in digital media (DICOM, JPEG, PNG, PDF, Microsoft Word (.doc, .docx, etc.) will facilitate faster and easier sharing through e-mail and provide great advantages in assessment of your disease.<\/p>\n<p>\u25cfContact details of you and your primary physician (home\/work\/cell phone number, e-mail address)<br \/>\n\u25cfMost up-to-date medical reports<br \/>\n\u25cfPathology reports<br \/>\n\u25cfBlood tests<br \/>\n\u25cfTotal body bone scan, CT, MRI and 68Ga-PSMA PET\/CT, 18F-FDG PET\/CT reports and original films\/CDs\/DVDs.<\/p>\n<p>If needed, your Nuclear Medicine Physician may order 18F-NaF PET\/CT or total body bone scan in order to assess your eligibility for treatment and bone mineral density measurement in order to investigate osteoporosis.<br \/>\nYou will also be asked to have following blood tests. As these tests are expected to show your condition during treatment, they should have been made at least 2 weeks before the treatment. The tests will be done before the treatment and each treatment cycle.<\/p>\n<p>\u25cfPSA<br \/>\n\u25cfComplete blood count<br \/>\n\u25cfAlkaline phosphatase<\/p>\n<p>Your physician may order additional blood tests.<br \/>\nRadium-223 therapy does not require dose modification for patients with liver and kidney failure.<br \/>\nPatients with bone fractures or spinal cord compression will be asked to have those conditions treated before the treatment.<br \/>\nYou need to make sure minimum 4 weeks have passed from your last cycle, if chemotherapy was administered to you.<br \/>\nWe recommend you to take with you loose and comfortable clothes from home since you will be wearing your own clothes throughout the treatment. Short sleeved or large cuffed clothes will help you, since intravenous access will be inserted into a blood vessel on your arm or back of your hand for treatment and concomitant tests.<br \/>\nSince Radium-223 is excreted by intestines, additional supportive measures may be needed for patients with inflammatory bowel disease, such as \u201culcerative colitis\u201d and \u201cCrohn\u2019s Disease\u201d or history of intestinal obstruction.\n<\/p>\n<h3>How is Radium-223 Therapy Administered?<\/h3>\n<p>Standard Radium-223 therapy consists of six cycles in total with four-week intervals (6 times, each injection lasting one minute).<br \/>\nRadium-223 dichloride solution, which is manufactured for you and ready to be used, will be infused into your body through peripheral intravenous access at the Nuclear Medicine Clinic.<br \/>\nBefore Radium-223 is administered, minimum 10 ml of saline will be used to irrigate and check your intravenous access; Radium-223 will be slowly infused and administered over 1 minute, and then your intravenous access will be irrigated with minimum 10 ml of saline again. No pain is felt during the procedure.<br \/>\nRadium-223 dichloride will be rapidly cleansed from your blood following the infusion; its uptake will first occur in bones and bone metastases or it will be excreted to intestines.\n<\/p>\n<h3>Potential Side Effects and Instructions<\/h3>\n<p>Most common side effects of Radium-223 therapy are nausea, vomiting and diarrhea (\u2265 10%). Temporary decrease in blood counts is also likely.<\/p>\n<p><strong>Patients under treatment should follow the instructions given below:<\/strong><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Have blood count test done on the specified dates. Notify your physician about any bleeding or symptoms of infection.<\/li>\n<li>You should sufficiently hydrate by mouth; monitor hydration levels and urine output.<\/li>\n<li>Inform your physician if you are dehydrated or if any signs of kidney failure develop.<\/li>\n<li>No limitation is required regarding physical contacts with other people after the treatment.<\/li>\n<li>Preserve good hygiene during Radium-223 therapy and at least for 1 week following the date of last dose.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\u2013 Use the toilet in a sitting position and flush at least twice after each use.<br \/>\u2013 Immediately wash your clothes contaminated with urine and stool separately from other clothes.<\/p>\n<ul>\n<li>Your caretakers should wear gloves when touching your bodily fluids and wash their hands afterwards in order to prevent infection.<\/li>\n<\/ul>\n<li>Patients with active sex life should use condoms, and their female partners with conception potential should use an effective contraception method during 6 months after the treatment.<\/p>\n<p><a href=\"https:\/\/www.intheranostics.com\/iletisim\/\"><strong>Please contact us for further details.<\/strong><\/a><\/p>\n<p>[\/et_pb_text][et_pb_accordion disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;%224.4.8%22&#8243; disabled=&#8221;on&#8221;][et_pb_accordion_item title=&#8221;%22TANI&#8221; open=&#8221;on&#8221; open_toggle_text_color=&#8221;%22#0ca7c5%22&#8243; _builder_version=&#8221;%224.4.8%22&#8243; toggle_font=&#8221;%22|700|||||||%22&#8243; toggle_font_size=&#8221;%2218px%22&#8243;]<\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT Nedir, T\u00fcm\u00f6r Oda\u011f\u0131n\u0131 Nas\u0131l G\u00f6sterir?<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b><span style=\"float: none;background-color: #ffffff;color: #666666;font-family: 'Quicksand',Helvetica,Arial,Lucida,sans-serif;font-size: 100%;font-style: normal;font-variant: normal;font-weight: 500;letter-spacing: normal;text-align: left;text-decoration: none;text-indent: 0px;text-transform: none\">Teranostik t\u0131p d\u00fcnyas\u0131nda yeni geli\u015fmekte olan bir aland\u0131r. T\u00fcm\u00f6re \u00f6zg\u00fcl bir ila\u00e7 ile g\u00f6r\u00fcnt\u00fcleme yaparak saptanan t\u00fcm\u00f6r ve metastazlar\u0131n\u0131n, nereye gidece\u011fi, ne kadar gidece\u011fi ve hastal\u0131kl\u0131 dokuyu etkileme g\u00fcc\u00fc \u00f6nceden bilinen yine \u00f6zg\u00fcl bir ila\u00e7 ile tedavi edilebildi\u011fi bir yakla\u015f\u0131md\u0131r. Bu yakla\u015f\u0131m, geleneksel t\u0131ptan ki\u015fiye \u00f6zg\u00fc \u00e7a\u011fda\u015f t\u0131p uygulamalar\u0131na ge\u00e7i\u015f yap\u0131lmas\u0131n\u0131 sa\u011flamaktad\u0131r.<\/span><\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Prostat kanserinden \u00f6l\u00fcmler genellikle kemik metastaz\u0131 ve komplikasyonlar\u0131ndan kaynaklanmaktad\u0131r. Prostat kanseri kemik metastazlar\u0131\u00a0Flor-18 NaF (<\/span><span class=\"s2\"><sup>18<\/sup><\/span><span class=\"s1\">F-NaF) PET\/BT ile y\u00fcksek duyarl\u0131l\u0131kla g\u00f6r\u00fcnt\u00fclenebilmekte ve Radyum-223 ile bu t\u00fcm\u00f6ral dokular\u0131n \u00f6zg\u00fcl ve hedefe y\u00f6nelik tedavisi yap\u0131labilmektedir. Bu, teranostik uygulamalar i\u00e7in olduk\u00e7a ba\u015far\u0131l\u0131 bir \u00f6rnektir.<\/span><\/p>\n<p class=\"p4\"><span class=\"s1\">Hastal\u0131\u011f\u0131n\u0131z\u0131 takip eden hekiminiz, kemik metastazlar\u0131n\u0131n tan\u0131s\u0131 amac\u0131yla size bu tetkiki \u00f6nerebilir.\u00a0F-18 NaF PET\/BT; kemik metastazlar\u0131n\u0131n yeri ve yayg\u0131nl\u0131\u011f\u0131n\u0131 do\u011fru bir \u015fekilde g\u00f6sterirken a\u011fr\u0131l\u0131 kemik metastazlar\u0131nda hedefe y\u00f6nelik ba\u015far\u0131l\u0131 bir tedavi se\u00e7ene\u011fi olan Radyum-223 tedavisinin kullan\u0131m\u0131n\u0131 da m\u00fcmk\u00fcn k\u0131lar.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT\u2019nin \u00dcst\u00fcn Yanlar\u0131 Nelerdir?<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">F-18 NaF PET\/BT, kemik g\u00f6r\u00fcnt\u00fcleme maddesi olarak ideal \u00f6zelliklere sahiptir ve 45-60 dakika gibi k\u0131sa bir s\u00fcre i\u00e7inde \u00fcst\u00fcn kalitede g\u00f6r\u00fcnt\u00fcler \u00fcretir.\u00a0Ba\u015fta kemik metastaz\u0131 ara\u015ft\u0131r\u0131lan hastalar olmak \u00fczere bir\u00e7ok hasta i\u00e7in,\u00a0F-18 NaF PET\/BT, geleneksel kemik sintigrafisine g\u00f6re \u00e7ok daha ba\u015far\u0131l\u0131 sonu\u00e7lar\u0131 ile ideal bir alternatiftir.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT Kimlere Uygulan\u0131r?<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Hastal\u0131\u011f\u0131n\u0131z\u0131 takip eden hekiminiz sizden\u00a0F-18 NaF PET\/BT taramas\u0131n\u0131 \u015fu ama\u00e7lar i\u00e7in isteyebilir:<\/span><\/p>\n<ul>\n<li class=\"p4\"><span class=\"s1\">Kemik metastazlar\u0131n\u0131n belirlenmesi<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">Hastal\u0131\u011f\u0131n yayg\u0131nl\u0131\u011f\u0131n\u0131n do\u011fru belirlenmesi<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">Malign kemik lezyonlar\u0131n\u0131n yerinin belirlenmesi<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">Kemik a\u011fr\u0131lar\u0131n\u0131n sa\u011falt\u0131m\u0131 i\u00e7in Radyum-223 tedavisinin uygun olup olmad\u0131\u011f\u0131n\u0131n belirlenmesi<\/span><\/li>\n<li class=\"p4\">Tedavi yan\u0131t\u0131n\u0131n de\u011ferlendirilmesi<\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT G\u00fcvenli midir?<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">F-18 NaF bilinen yan etkisi olmayan g\u00fcvenli bir radyoaktif maddedir. Bu i\u015flemde al\u0131nan radyasyon dozu azd\u0131r ve g\u00fcn sonunda v\u00fccudunuzdan temizlenir. N\u00fckleer T\u0131p klini\u011finden ayr\u0131lman\u0131z birka\u00e7 saat s\u00fcrmektedir. PET\/BT taramas\u0131n\u0131 izleyen 6 saat boyunca ba\u015fkalar\u0131yla (\u00f6zellikle \u00e7ocuklar ve hamile kad\u0131nlar) temas\u0131n\u0131z\u0131 en aza indirmenizi \u00f6nermekteyiz.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT \u00d6ncesi Haz\u0131rl\u0131k<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">F-18 NaF PET\/BT g\u00f6r\u00fcnt\u00fclemesi \u00f6ncesinde N\u00fckleer T\u0131p b\u00f6l\u00fcm\u00fcne iletmek \u00fczere, hastal\u0131\u011f\u0131n\u0131za y\u00f6nelik baz\u0131 tetkik ve bilgileri yan\u0131n\u0131zda bulundurman\u0131z istenecektir:<\/span><\/p>\n<ul>\n<li class=\"p4\"><span class=\"s1\">Hekim istem formu<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">Prostat kanseri hikayeniz (\u00f6rn. PSA, patoloji sonu\u00e7lar\u0131)<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">\u00d6nceki onkolojik tedavilerinizin tipi ve tarihi (\u00f6rn. kemoterapi ve\/veya radyoterapi)<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">\u00d6nceki k\u0131r\u0131klar\u0131n\u0131z veya yak\u0131n tarihli travma hikayeniz (yeri ve tarihi)<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">\u00d6nceki ortopedik cerrahi giri\u015fimleriniz (m\u00fcdahale tarihi, tipi ve yeri)<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">\u00d6nceki enfeksiyon ve yeri<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">\u0130drar yolu ile ilgili ge\u00e7irilmi\u015f ameliyatlar<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">Her bir kemik a\u011fr\u0131n\u0131z\u0131n yeri<\/span><\/li>\n<li class=\"p4\"><span class=\"s1\">Di\u011fer g\u00f6r\u00fcnt\u00fclemeler ve raporlar\u0131 (\u00f6zellikle kemik sintigrafisi, BT veya MRI)<\/span><\/li>\n<\/ul>\n<p class=\"p2\"><span class=\"s1\">F-18 NaF PET\/BT i\u015flemi i\u00e7in a\u00e7 olman\u0131za gerek yoktur. \u0130la\u00e7lar\u0131n\u0131z\u0131 her zamanki gibi alabilirsiniz. <\/span><span class=\"s1\">B\u00f6brekten at\u0131l\u0131m\u0131 art\u0131rmak, al\u0131nan radyasyon dozunu azaltmak ve en iyi g\u00f6r\u00fcnt\u00fc kalitesine ula\u015fmak i\u00e7in,\u00a0F-18 NaF enjeksiyonu \u00f6ncesinde ve sonras\u0131nda en az iki\u015fer bardak su i\u00e7melisiniz. Tetkik sonras\u0131nda g\u00fcn\u00fcn geri kalan\u0131nda da su i\u00e7meye devam etmeniz faydal\u0131 olacakt\u0131r.\u00a0\u0130\u015flem s\u0131ras\u0131nda g\u00f6r\u00fcnt\u00fc bozulmalar\u0131n\u0131 \u00f6nlemek i\u00e7in t\u00fcm metal e\u015fyalar\/tak\u0131lar\/protezler \u00e7\u0131kar\u0131lmal\u0131d\u0131r.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT Nas\u0131l Uygulan\u0131r?<\/b><\/span><\/p>\n<p class=\"p4\"><span class=\"s1\">Az miktarda (1.5-3.7 Mbq\/Kg (0.04-0.1 mCi\/Kg) dozunda) F-18-NaF, g\u00f6r\u00fcnt\u00fcleme i\u015fleminden yakla\u015f\u0131k 30-60 dakika \u00f6nce, kol ya da el s\u0131rt\u0131n\u0131za yerle\u015ftirdi\u011fimiz damar yolundan uygulanacakt\u0131r.\u00a0<\/span><span class=\"s1\">F-18 NaF PET\/BT g\u00f6r\u00fcnt\u00fclemesinden hemen \u00f6nce mesanenizi bo\u015faltman\u0131z gerekmektedir.<\/span><\/p>\n<p class=\"p4\"><span class=\"s1\">PET\/BT g\u00f6r\u00fcnt\u00fclemesi boyunca (yakla\u015f\u0131k 20-25 dk.), v\u00fccut g\u00f6r\u00fcnt\u00fclerinin s\u00fcrekli kaydedildi\u011fi, her iki ucu a\u00e7\u0131k, geni\u015f halka \u015feklindeki bir cihazda, \u00f6zel \u00e7ekim yata\u011f\u0131 \u00fczerinde uzanman\u0131z istenecektir. \u0130\u015flemin tek zahmetli yan\u0131; bu s\u00fcre zarf\u0131nda hareketsiz kalman\u0131zd\u0131r. \u0130htiyac\u0131n\u0131z halinde, g\u00f6r\u00fcnt\u00fcleme \u00f6ncesi, beraberinizde getirdi\u011finiz a\u011fr\u0131 kesicinizi kullanabilirsiniz.<\/span><\/p>\n<p class=\"p4\"><span class=\"s1\">\u0130htiya\u00e7 duyulursa uzmanlar\u0131m\u0131z ek g\u00f6r\u00fcnt\u00fc alabilir. Ek g\u00f6r\u00fcnt\u00fcleme i\u015flemi yakla\u015f\u0131k 10-15 dakika s\u00fcrmektedir. <\/span><span class=\"s1\">N\u00fckleer T\u0131p klini\u011findeki i\u015flemlerin tamamlanmas\u0131 birka\u00e7 saati bulabilir. <\/span><span class=\"s1\">Kolunuzdaki damar yolu, g\u00f6r\u00fcnt\u00fclemeniz tamamland\u0131ktan ve t\u00fcm g\u00f6r\u00fcnt\u00fcleriniz kontrol edildikten sonra \u00e7\u0131kart\u0131lacakt\u0131r. Sa\u011fl\u0131k personelimizin onay vermesiyle, N\u00fckleer T\u0131p b\u00f6l\u00fcm\u00fcnden art\u0131k g\u00fcvenle ayr\u0131labilirsiniz.<\/span><\/p>\n<p class=\"p4\"><span class=\"s1\">\u0130la\u00e7 verildikten sonra ilk 6 saat k\u00fc\u00e7\u00fck \u00e7ocuklarla ve hamile kad\u0131nlarla temastan ka\u00e7\u0131nman\u0131z gerekti\u011fini l\u00fctfen unutmay\u0131n\u0131z. G\u00f6r\u00fcnt\u00fcleriniz N\u00fckleer T\u0131p Uzmanlar\u0131m\u0131z taraf\u0131ndan belirtilen s\u00fcrede de\u011ferlendirilerek rapor edilecektir.<\/span><\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;TEDAV\u0130 H\u0130ZMETLER\u0130 &#8211; RADYUM-223 TEDAV\u0130S\u0130&#8221; open_toggle_text_color=&#8221;#0ca7c5&#8243; _builder_version=&#8221;4.4.8&#8243; toggle_font=&#8221;|700|||||||&#8221; toggle_font_size=&#8221;18px&#8221; open=&#8221;off&#8221;]<\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi Nedir?<\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Teranostik t\u0131p d\u00fcnyas\u0131nda yeni geli\u015fmekte olan bir aland\u0131r. T\u00fcm\u00f6re \u00f6zg\u00fcl bir ila\u00e7 ile g\u00f6r\u00fcnt\u00fcleme yaparak saptanan t\u00fcm\u00f6r ve metastazlar\u0131n\u0131n, nereye gidece\u011fi-ne kadar gidece\u011fi ve hastal\u0131kl\u0131 dokuyu etkileme g\u00fcc\u00fc \u00f6nceden bilinen yine \u00f6zg\u00fcl bir ila\u00e7 ile tedavi edilebildi\u011fi bir yakla\u015f\u0131md\u0131r. Bu yakla\u015f\u0131m, geleneksel t\u0131ptan ki\u015fiye \u00f6zg\u00fc \u00e7a\u011fda\u015f t\u0131p uygulamalar\u0131na ge\u00e7i\u015f yap\u0131lmas\u0131n\u0131 sa\u011flamaktad\u0131r.<\/span><\/p>\n<p class=\"p2\">Prostat kanseri<strong>\u00a0<\/strong>v\u00fccudun di\u011fer b\u00f6lgelerine yay\u0131ld\u0131\u011f\u0131nda, s\u0131kl\u0131kla kemiklerde yerle\u015fmektedir. Kemik metastaz\u0131 a\u011fr\u0131 d\u0131\u015f\u0131nda, k\u0131r\u0131k, omurilik s\u0131k\u0131\u015fmas\u0131 veya hayat\u0131 tehdit edebilen y\u00fcksek kan kalsiyum seviyeleri gibi ba\u015fka sorunlara da neden olabilir. Kanser kemiklere ula\u015ft\u0131\u011f\u0131nda, a\u011fr\u0131y\u0131 ve di\u011fer komplikasyonlar\u0131 kontrol etmek veya hafifletmek tedavinin \u00e7ok \u00f6nemli bir par\u00e7as\u0131d\u0131r. Hormon tedavisi, kemoterapi ve a\u015f\u0131lar gibi tedaviler buna yard\u0131mc\u0131 olabilir. Ancak uygun hastalarda, \u00f6zellikle kemik metastaz\u0131n\u0131 hedef alan ve alfa \u0131\u015f\u0131mas\u0131 yapan Radyum-223 tedavisi ile bir yandan semptomlar kontrol alt\u0131na al\u0131n\u0131rken bir yandan da sa\u011f kal\u0131m\u0131 art\u0131r\u0131c\u0131 etki sa\u011flanabilmektedir.<\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Nas\u0131l Tedavi Eder?<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Radyum-223, kemik metastazlar\u0131na se\u00e7ici olarak ba\u011flanan ve \u00e7ok k\u0131sa menzilli y\u00fcksek enerjili par\u00e7ac\u0131klar\u0131 (&lt;100 \u03bcm) yayan, radyoaktif bir elementtir. Radyum-223 diklor\u00fcr molek\u00fcl\u00fc, kalsiyumu taklit ederek kemik metastazlar\u0131na ba\u011flan\u0131r ve ard\u0131ndan y\u00fcksek enerjili alfa par\u00e7ac\u0131\u011f\u0131na ait radyasyon, DNA k\u0131r\u0131klar\u0131na neden olarak t\u00fcm\u00f6r h\u00fccrelerini \u00f6ld\u00fcr\u00fcr. Alfa par\u00e7ac\u0131klar\u0131n\u0131n k\u0131sa olan menzili, kom\u015fu sa\u011fl\u0131kl\u0131 doku ve \u00f6zellikle kemik ili\u011fi \u00fczerindeki zararl\u0131 etkinin de en az d\u00fczeyde kalmas\u0131 anlam\u0131na gelmektedir.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Sa\u011f kal\u0131m\u0131 uzatt\u0131\u011f\u0131 bilinen kemi\u011fe \u00f6zg\u00fc tek ila\u00e7, radyoaktif alfa par\u00e7ac\u0131\u011f\u0131 yayarak tedavi edici etkisini g\u00f6steren Radyum-223&#8217;t\u00fcr. Bilimsel \u00e7al\u0131\u015fmalar ile Radyum-223 tedavisinin ortalama ya\u015fam s\u00fcresini uzatt\u0131\u011f\u0131 g\u00f6sterilmi\u015ftir. Buna ek olarak a\u011fr\u0131da ve ya\u015fam kalitesinde iyile\u015fmeyi sa\u011flamaktad\u0131r. T\u00fcm bu faydalar\u0131n\u0131n yan\u0131nda kan de\u011ferlerinde ge\u00e7ici d\u00fc\u015fme ve ishal d\u0131\u015f\u0131nda Radyum-223 tedavisi ile ili\u015fkili yan etkiler olduk\u00e7a hafif d\u00fczeylerde izlenmi\u015ftir.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi Kimlere Uygulan\u0131r?<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisi \u00e7ok spesifik bir tedavi t\u00fcr\u00fcd\u00fcr, bu nedenle sadece kemiklere yay\u0131lm\u0131\u015f ve a\u011fr\u0131 \u015fikayeti olan prostat kanserli hastalarda, takip eden hekimleri taraf\u0131ndan uygun g\u00f6r\u00fclmesi durumunda uygulanabilir.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisi, kemi\u011fe yay\u0131lm\u0131\u015f kanserin s\u0131kl\u0131kla neden oldu\u011fu a\u011fr\u0131y\u0131 hafifletebilir. Bu tedavinin uygulanmas\u0131na karar verildi\u011finde, tedavi \u00f6ncesinde, t\u00fcm v\u00fccut kemik taramas\u0131 (\u00f6rn. F-NaF PET\/BT, kemik sintigrafisi) yap\u0131lmaktad\u0131r. Bu, Radyum-223&#8217;\u00fcn tedavi s\u0131ras\u0131nda do\u011fru alanlar\u0131 hedefledi\u011finden emin olunmas\u0131n\u0131 sa\u011flayacakt\u0131r.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi G\u00fcvenli midir?<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisinde kullan\u0131lan alfa radyasyonu \u00e7ok y\u00fcksek bir enerji seviyesine sahiptir. Bununla birlikte alfa radyasyon, do\u011fas\u0131 gere\u011fi sadece \u00e7ok k\u0131sa mesafelere (iki ila on h\u00fccre mesafesinde) seyahat eder ve bu da radyasyonun yok edici etkisinin sa\u011fl\u0131kl\u0131 h\u00fccrelerde de\u011fil, kemikteki kanser h\u00fccrelerinde olu\u015fmas\u0131n\u0131 sa\u011flamaktad\u0131r. Sa\u011fl\u0131kl\u0131 h\u00fccrelerce al\u0131nan minimal radyasyon dozu, Radium-223 tedavisi ile ili\u015fkili yan etkilerin de ihmal edilebilir d\u00fczeyde oldu\u011fu anlam\u0131na gelir ve \u00fcretilen kan h\u00fccrelerinin say\u0131s\u0131nda ge\u00e7ici bir azalma ve nadiren bulant\u0131, kusma ve ishal, tedavi olan hastalar\u0131m\u0131zda g\u00f6r\u00fclebilmektedir.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi \u00d6ncesi Haz\u0131rl\u0131k \u00a0<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Klini\u011fe ilk ba\u015fvurunuzda, a\u015fa\u011f\u0131da listelenen bilgi ve belgeleri beraberinizde getirmeniz \u00f6nemlidir. Hasta bilgilerinizin dijital ortamda haz\u0131rlanmas\u0131 (DICOM, JPEG, PNG, PDF, Microsoft Word (.doc, .docx, vb.)), e-posta ile h\u0131zl\u0131 ve kolayca payla\u015f\u0131lmas\u0131na imkan tan\u0131yacak ve hastal\u0131\u011f\u0131n\u0131z\u0131n de\u011ferlendirilmesini b\u00fcy\u00fck oranda kolayla\u015ft\u0131racakt\u0131r:<\/span><\/p>\n<ul>\n<li class=\"p2\"><span class=\"s1\">Sizin ve sizi takip eden hekiminizin ileti\u015fim bilgileri (ev\/i\u015f\/cep telefon numaras\u0131, e-posta adresi)<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">En g\u00fcncel hekim raporlar\u0131<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Patoloji raporlar\u0131<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Kan testleri<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">T\u00fcm v\u00fccut kemik sintigrafisi, BT, MR ve 68Ga-PSMA PET\/BT, 18F-FDG PET\/BT raporlar\u0131 ve orijinal film\/CD\/DVD&#8217;leri<\/span><\/li>\n<\/ul>\n<p class=\"p2\"><span class=\"s1\">N\u00fckleer T\u0131p Hekiminiz, bu tedavi \u00f6ncesinde ihtiya\u00e7 duyulmas\u0131 halinde, tedaviye uygunlu\u011funuzu de\u011ferlendirmek amac\u0131yla 18F-NaF PET\/BT veya t\u00fcm v\u00fccut kemik sintigrafisi g\u00f6r\u00fcnt\u00fclemeleri ile kemik erimesi varl\u0131\u011f\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 i\u00e7in kemik mineral yo\u011funlu\u011fu \u00f6l\u00e7\u00fcm\u00fc isteyebilir.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Ayr\u0131ca a\u015fa\u011f\u0131daki kan testlerini yapt\u0131rman\u0131z istenecektir. Bu testlerin, tedavi s\u0131ras\u0131ndaki durumunuzu g\u00f6stermesi beklendi\u011finden, tedaviden en ge\u00e7 2 hafta \u00f6nce yap\u0131lm\u0131\u015f olmas\u0131 gerekmektedir. Bu testler tedaviye ba\u015flarken ve her tedavi k\u00fcr\u00fcnden \u00f6nce yap\u0131lacakt\u0131r.<\/span><\/p>\n<ul>\n<li class=\"p2\"><span class=\"s1\">PSA<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Tam kan say\u0131m\u0131<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Alkalen fosfataz<\/span><\/li>\n<\/ul>\n<p class=\"p2\"><span class=\"s1\">Hekiminiz, gerekti\u011finde ek kan testleri de isteyebilir. <\/span><span class=\"s1\">Karaci\u011fer ve b\u00f6brek yetmezli\u011fi olan hastalar\u0131m\u0131zda, Radyum-223 tedavisi herhangi bir doz ayarlamas\u0131na gitmeden uygulanabilir.<\/span><span class=\"s1\">Kemik k\u0131r\u0131\u011f\u0131 ya da omurilik bas\u0131s\u0131 olan hastalar\u0131m\u0131zda ise \u00f6ncelikle bu sorunlar\u0131n d\u00fczeltilmesi istenecektir.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Kemoterapi tedavisi ald\u0131ysan\u0131z en son k\u00fcr\u00fcn \u00fczerinden en az 4 hafta ge\u00e7ti\u011finden emin olman\u0131z gerekmektedir.<\/span><span class=\"s1\">Tedavi s\u0131ras\u0131nda evden getirdi\u011finiz kendi giysilerinizi giyece\u011finiz i\u00e7in rahat ve geni\u015f k\u0131yafetler tercih etmenizi \u00f6neririz. Tedaviniz ve birlikte yap\u0131lan testler i\u00e7in kolunuza veya elinizin s\u0131rt\u0131na yerle\u015ftirilen damar yolu kullan\u0131laca\u011f\u0131ndan, k\u0131sa kollu ya da geni\u015f kollu giysileri bulundurman\u0131z yararl\u0131 olacakt\u0131r.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Radyum-223 ba\u011f\u0131rsaktan at\u0131ld\u0131\u011f\u0131 i\u00e7in \u201c\u00fclseratif kolit\u201d ve \u201cCrohn hastal\u0131\u011f\u0131\u201d gibi enflamatuar ba\u011f\u0131rsak hastal\u0131\u011f\u0131 olan ya da ba\u011f\u0131rsak t\u0131kan\u0131kl\u0131\u011f\u0131 hikayesi bulunan hastalar\u0131m\u0131zda ek destekleyici \u00f6nlemler almam\u0131z gerekebilir.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi Nas\u0131l Uygulan\u0131r?<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Standard Radyum-223 tedavisi; d\u00f6rt haftal\u0131k aral\u0131klarla, toplam alt\u0131 tedavi k\u00fcr\u00fcnden (6 adet, birer dakikal\u0131k enjeksiyon) olu\u015fmaktad\u0131r. <\/span><span class=\"s1\">Sizin i\u00e7in \u00fcretilmi\u015f, kullan\u0131ma haz\u0131r Radyum-223 diklor\u00fcr \u00e7\u00f6zeltisi, N\u00fckleer T\u0131p Klini\u011finde, yerle\u015ftirdi\u011fimiz periferik damar yoluyla enjekte edilecektir.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Radyum-223 uygulamadan \u00f6nce, damar yolunuzun a\u00e7\u0131kl\u0131\u011f\u0131, en az 10 ml serum fizyolojik ile y\u0131kanarak kontrol edilecek ve Radyum-223 yakla\u015f\u0131k 1 dakika boyunca yava\u015f enjeksiyon \u015feklinde uygulanacak, sonras\u0131nda damar yolunuz yine en az 10 ml serum fizyolojik ile y\u0131kanacakt\u0131r. Bu i\u015flem s\u0131ras\u0131nda a\u011fr\u0131 hissedilmemektedir.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Enjeksiyondan sonra Radyum-223 diklor\u00fcr h\u0131zla kandan temizlenecek ve \u00f6ncelikle kemik ve kemik metastazlar\u0131nda tutulacak veya ba\u011f\u0131rsa\u011fa at\u0131lacakt\u0131r.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>Olas\u0131 Yan Etkiler ve Talimatlar<\/b><\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisi uygulanan hastalar\u0131m\u0131zda g\u00f6r\u00fclebilecek en yayg\u0131n yan etkiler (\u2265% 10) bulant\u0131, kusma ve ishaldir. Ayr\u0131ca kan h\u00fccre say\u0131s\u0131nda ge\u00e7ici d\u00fc\u015fmeler g\u00f6r\u00fclebilmektedir.<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">Tedavi alan hastalar\u0131m\u0131z\u0131n a\u015fa\u011f\u0131daki talimatlara uymalar\u0131 \u00f6nemlidir:\u00a0\u00a0<\/span><\/p>\n<ul>\n<li class=\"p2\"><span class=\"s1\">Size belirtilen tarihlerde kan say\u0131m\u0131n\u0131z\u0131 yapt\u0131r\u0131n\u0131z. Kanama veya enfeksiyon belirtilerini hekiminize iletiniz.<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">A\u011f\u0131zdan su al\u0131m\u0131n\u0131z iyi d\u00fczeyde olmal\u0131d\u0131r, v\u00fccut su d\u00fczeyi ve idrar \u00e7\u0131k\u0131\u015f\u0131n\u0131z\u0131 takip ediniz.<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">V\u00fccudunuzun susuz kalmas\u0131 veya b\u00f6brek yetmezli\u011fi belirtileri geli\u015firse hekiminize bildiriniz.<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Tedavi sonras\u0131 di\u011fer insanlarla temas konusunda herhangi bir k\u0131s\u0131tlaman\u0131z yoktur.<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Radyum-223 al\u0131rken ve son enjeksiyondan sonra en az 1 hafta boyunca iyi hijyen uygulamalar\u0131na dikkat ediniz.<br \/>\n<\/span><span class=\"s1\">&#8211; Klozeti oturarak kullan\u0131n\u0131z ve her kullan\u0131mdan sonra sifonu en az 2 kez \u00e7ekiniz.<br \/>\n<\/span><span class=\"s1\">&#8211; \u0130drar ve d\u0131\u015fk\u0131 ile kirlenmi\u015f giysilerinizi derhal ve di\u011fer k\u0131yafetlerden ayr\u0131 olarak y\u0131kay\u0131n\u0131z.<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Bak\u0131c\u0131lar\u0131n\u0131z, bula\u015f\u0131 \u00f6nlemek i\u00e7in v\u00fccut s\u0131v\u0131lar\u0131n\u0131z\u0131 tutarken eldiven kullanmal\u0131, sonras\u0131nda ellerini y\u0131kamal\u0131d\u0131r.<\/span><\/li>\n<li class=\"p2\"><span class=\"s1\">Cinsel olarak aktif olan hastalar\u0131m\u0131z prezervatif kullanmal\u0131 ve \u00fcreme potansiyeli olan kad\u0131n partnerleri de tedavi s\u0131ras\u0131nda ve tedavinin tamamlanmas\u0131n\u0131 takip eden 6 ay boyunca etkili bir do\u011fum kontrol y\u00f6ntemi uygulamal\u0131d\u0131r.<\/span><\/li>\n<\/ul>\n<p class=\"p2\"><span class=\"s1\"><i>Daha fazla bilgi i\u00e7in l\u00fctfen bizimle irtibata ge\u00e7iniz.<\/i><\/span><\/p>\n<p>[\/et_pb_accordion_item][\/et_pb_accordion][et_pb_code _builder_version=&#8221;4.4.8&#8243;][\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.4.8&#8243; background_color=&#8221;rgba(0,0,0,0)&#8221; background_image=&#8221;https:\/\/www.intheranostics.com\/wp-content\/uploads\/2020\/06\/metastatik_prostat_kanseri.jpg&#8221; custom_padding=&#8221;100px||100px||false|false&#8221; locked=&#8221;off&#8221;][et_pb_fullwidth_header title=&#8221;Radium-223 Therapy&#8221; text_orientation=&#8221;center&#8221; content_max_width_last_edited=&#8221;off|desktop&#8221; _builder_version=&#8221;4.4.8&#8243; title_font_size=&#8221;50px&#8221; content_font_size=&#8221;41px&#8221; subhead_font=&#8221;|700|||||||&#8221; subhead_font_size=&#8221;38px&#8221; subhead_line_height=&#8221;1.1em&#8221; background_enable_color=&#8221;off&#8221; background_enable_image=&#8221;off&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221;][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.4.8&#8243; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221;][et_pb_row _builder_version=&#8221;4.4.8&#8243; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.4.8&#8243;][et_pb_divider divider_weight=&#8221;0px&#8221; _builder_version=&#8221;4.4.8&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_start=&#8221;#8dd2e1&#8243; background_color_gradient_end=&#8221;#23afca&#8221; background_color_gradient_direction=&#8221;90deg&#8221; width=&#8221;50%&#8221; module_alignment=&#8221;center&#8221; height=&#8221;10px&#8221;][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; _builder_version=&#8221;4.4.8&#8243;][et_pb_row admin_label=&#8221;row&#8221; _builder_version=&#8221;4.4.8&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" fullwidth=\"on\" _builder_version=\"4.4.8\" background_color=\"rgba(0,0,0,0)\" background_image=\"https:\/\/www.intheranostics.com\/wp-content\/uploads\/2020\/06\/metastatik_prostat_kanseri.jpg\" custom_padding=\"100px||100px||false|false\" locked=\"off\"][et_pb_fullwidth_header title=\"Radyum-223 Tedavisi \" text_orientation=\"center\" content_max_width_last_edited=\"off|desktop\" _builder_version=\"4.4.8\" title_font_size=\"50px\" content_font_size=\"41px\" subhead_font=\"|700|||||||\" subhead_font_size=\"38px\" subhead_line_height=\"1.1em\" background_enable_color=\"off\" background_enable_image=\"off\" custom_margin=\"||||false|false\" custom_padding=\"||||false|false\" animation_style=\"slide\" animation_direction=\"bottom\"][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.4.8\" custom_margin=\"0px||0px||false|false\" custom_padding=\"0px|0px|0px|0px|false|false\"][et_pb_row _builder_version=\"4.4.8\" custom_margin=\"0px||||false|false\" custom_padding=\"0px|0px|0px|0px|false|false\"][et_pb_column type=\"4_4\" _builder_version=\"4.4.8\"][et_pb_divider divider_weight=\"0px\" _builder_version=\"4.4.8\" use_background_color_gradient=\"on\" background_color_gradient_start=\"#8dd2e1\" background_color_gradient_end=\"#23afca\" background_color_gradient_direction=\"90deg\" width=\"50%\" module_alignment=\"center\" height=\"10px\"][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" admin_label=\"section\" _builder_version=\"4.4.8\"][et_pb_row admin_label=\"row\" _builder_version=\"4.4.8\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_margin=\"||||false|false\" custom_padding=\"0px|0px|0px|0px|false|false\"][et_pb_column type=\"4_4\" _builder_version=\"3.25\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.4.8\"]<h2>Radyum-223 Tedavisi Nedir?<\/h2>\r\n<p>Teranostik t\u0131p d\u00fcnyas\u0131nda yeni geli\u015fmekte olan bir aland\u0131r. T\u00fcm\u00f6re \u00f6zg\u00fcl bir ila\u00e7 ile g\u00f6r\u00fcnt\u00fcleme yaparak saptanan t\u00fcm\u00f6r ve metastazlar\u0131n\u0131n, nereye gidece\u011fi-ne kadar gidece\u011fi ve hastal\u0131kl\u0131 dokuyu etkileme g\u00fcc\u00fc \u00f6nceden bilinen yine \u00f6zg\u00fcl bir ila\u00e7 ile tedavi edilebildi\u011fi bir yakla\u015f\u0131md\u0131r. Bu yakla\u015f\u0131m, geleneksel t\u0131ptan ki\u015fiye \u00f6zg\u00fc \u00e7a\u011fda\u015f t\u0131p uygulamalar\u0131na ge\u00e7i\u015f yap\u0131lmas\u0131n\u0131 sa\u011flamaktad\u0131r.<\/p>\r\n<p>Prostat kanseri v\u00fccudun di\u011fer b\u00f6lgelerine yay\u0131ld\u0131\u011f\u0131nda, s\u0131kl\u0131kla kemiklerde yerle\u015fmektedir. Kemik metastaz\u0131 a\u011fr\u0131 d\u0131\u015f\u0131nda, k\u0131r\u0131k, omurilik s\u0131k\u0131\u015fmas\u0131 veya hayat\u0131 tehdit edebilen y\u00fcksek kan kalsiyum seviyeleri gibi ba\u015fka sorunlara da neden olabilir. Kanser kemiklere ula\u015ft\u0131\u011f\u0131nda, a\u011fr\u0131y\u0131 ve di\u011fer komplikasyonlar\u0131 kontrol etmek veya hafifletmek tedavinin \u00e7ok \u00f6nemli bir par\u00e7as\u0131d\u0131r. Hormon tedavisi, kemoterapi ve a\u015f\u0131lar gibi tedaviler buna yard\u0131mc\u0131 olabilir. Ancak uygun hastalarda, \u00f6zellikle kemik metastaz\u0131n\u0131 hedef alan ve alfa \u0131\u015f\u0131mas\u0131 yapan Radyum-223 tedavisi ile bir yandan semptomlar kontrol alt\u0131na al\u0131n\u0131rken bir yandan da sa\u011f kal\u0131m\u0131 art\u0131r\u0131c\u0131 etki sa\u011flanabilmektedir.<\/p>\r\n<h3>Radyum-223 Nas\u0131l Tedavi Eder?<\/h3>\r\n<p>Radyum-223, kemik metastazlar\u0131na se\u00e7ici olarak ba\u011flanan ve \u00e7ok k\u0131sa menzilli y\u00fcksek enerjili par\u00e7ac\u0131klar\u0131 (<100 \u03bcm) yayan, radyoaktif bir elementtir. Radyum-223 diklor\u00fcr molek\u00fcl\u00fc, kalsiyumu taklit ederek kemik metastazlar\u0131na ba\u011flan\u0131r ve ard\u0131ndan y\u00fcksek enerjili alfa par\u00e7ac\u0131\u011f\u0131na ait radyasyon, DNA k\u0131r\u0131klar\u0131na neden olarak t\u00fcm\u00f6r h\u00fccrelerini \u00f6ld\u00fcr\u00fcr. Alfa par\u00e7ac\u0131klar\u0131n\u0131n k\u0131sa olan menzili, kom\u015fu sa\u011fl\u0131kl\u0131 doku ve \u00f6zellikle kemik ili\u011fi \u00fczerindeki zararl\u0131 etkinin de en az d\u00fczeyde kalmas\u0131 anlam\u0131na gelmektedir.<\/p>\r\n<p>Sa\u011f kal\u0131m\u0131 uzatt\u0131\u011f\u0131 bilinen kemi\u011fe \u00f6zg\u00fc tek ila\u00e7, radyoaktif alfa par\u00e7ac\u0131\u011f\u0131 yayarak tedavi edici etkisini g\u00f6steren Radyum-223\u2019t\u00fcr. Bilimsel \u00e7al\u0131\u015fmalar ile Radyum-223 tedavisinin ortalama ya\u015fam s\u00fcresini uzatt\u0131\u011f\u0131 g\u00f6sterilmi\u015ftir. Buna ek olarak a\u011fr\u0131da ve ya\u015fam kalitesinde iyile\u015fmeyi sa\u011flamaktad\u0131r. T\u00fcm bu faydalar\u0131n\u0131n yan\u0131nda kan de\u011ferlerinde ge\u00e7ici d\u00fc\u015fme ve ishal d\u0131\u015f\u0131nda Radyum-223 tedavisi ile ili\u015fkili yan etkiler olduk\u00e7a hafif d\u00fczeylerde izlenmi\u015ftir.<\/p>\r\n<h3>Radyum-223 Tedavisi Kimlere Uygulan\u0131r?<\/h3>\r\n<p>Radyum-223 tedavisi \u00e7ok spesifik bir tedavi t\u00fcr\u00fcd\u00fcr, bu nedenle sadece kemiklere yay\u0131lm\u0131\u015f ve a\u011fr\u0131 \u015fikayeti olan prostat kanserli hastalarda, takip eden hekimleri taraf\u0131ndan uygun g\u00f6r\u00fclmesi durumunda uygulanabilir.<\/p>\r\n<p>Radyum-223 tedavisi, kemi\u011fe yay\u0131lm\u0131\u015f kanserin s\u0131kl\u0131kla neden oldu\u011fu a\u011fr\u0131y\u0131 hafifletebilir. Bu tedavinin uygulanmas\u0131na karar verildi\u011finde, tedavi \u00f6ncesinde, t\u00fcm v\u00fccut kemik taramas\u0131 (\u00f6rn. F-NaF PET\/BT, kemik sintigrafisi) yap\u0131lmaktad\u0131r. Bu, Radyum-223\u2019\u00fcn tedavi s\u0131ras\u0131nda do\u011fru alanlar\u0131 hedefledi\u011finden emin olunmas\u0131n\u0131 sa\u011flayacakt\u0131r.<\/p>\r\n<h3>Radyum-223 Tedavisi G\u00fcvenli midir?<\/h3>\r\n<p>Radyum-223 tedavisinde kullan\u0131lan alfa radyasyonu \u00e7ok y\u00fcksek bir enerji seviyesine sahiptir. Bununla birlikte alfa radyasyon, do\u011fas\u0131 gere\u011fi sadece \u00e7ok k\u0131sa mesafelere (iki ila on h\u00fccre mesafesinde) seyahat eder ve bu da radyasyonun yok edici etkisinin sa\u011fl\u0131kl\u0131 h\u00fccrelerde de\u011fil, kemikteki kanser h\u00fccrelerinde olu\u015fmas\u0131n\u0131 sa\u011flamaktad\u0131r. Sa\u011fl\u0131kl\u0131 h\u00fccrelerce al\u0131nan minimal radyasyon dozu, Radium-223 tedavisi ile ili\u015fkili yan etkilerin de ihmal edilebilir d\u00fczeyde oldu\u011fu anlam\u0131na gelir ve \u00fcretilen kan h\u00fccrelerinin say\u0131s\u0131nda ge\u00e7ici bir azalma ve nadiren bulant\u0131, kusma ve ishal, tedavi olan hastalar\u0131m\u0131zda g\u00f6r\u00fclebilmektedir.<\/p>\r\n<h3>Radyum-223 Tedavisi \u00d6ncesi Haz\u0131rl\u0131k<\/h3>\r\n<p>Klini\u011fe ilk ba\u015fvurunuzda, a\u015fa\u011f\u0131da listelenen bilgi ve belgeleri beraberinizde getirmeniz \u00f6nemlidir. Hasta bilgilerinizin dijital ortamda haz\u0131rlanmas\u0131 (DICOM, JPEG, PNG, PDF, Microsoft Word (.doc, .docx, vb.)), e-posta ile h\u0131zl\u0131 ve kolayca payla\u015f\u0131lmas\u0131na imkan tan\u0131yacak ve hastal\u0131\u011f\u0131n\u0131z\u0131n de\u011ferlendirilmesini b\u00fcy\u00fck oranda kolayla\u015ft\u0131racakt\u0131r:<\/p>\r\n<ul>\r\n<li>Sizin ve sizi takip eden hekiminizin ileti\u015fim bilgileri (ev\/i\u015f\/cep telefon numaras\u0131, e-posta adresi)<\/li>\r\n<li>En g\u00fcncel hekim raporlar\u0131<\/li>\r\n<li>Patoloji raporlar\u0131<\/li>\r\n<li>Kan testleri<\/li>\r\n<li>T\u00fcm v\u00fccut kemik sintigrafisi, BT, MR ve 68Ga-PSMA PET\/BT, 18F-FDG PET\/BT raporlar\u0131 ve orijinal film\/CD\/DVD\u2019leri<\/li>\r\n<\/ul>\r\n<p>N\u00fckleer T\u0131p Hekiminiz, bu tedavi \u00f6ncesinde ihtiya\u00e7 duyulmas\u0131 halinde, tedaviye uygunlu\u011funuzu de\u011ferlendirmek amac\u0131yla 18F-NaF PET\/BT veya t\u00fcm v\u00fccut kemik sintigrafisi g\u00f6r\u00fcnt\u00fclemeleri ile kemik erimesi varl\u0131\u011f\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 i\u00e7in kemik mineral yo\u011funlu\u011fu \u00f6l\u00e7\u00fcm\u00fc isteyebilir.<\/p>\r\n<p>Ayr\u0131ca a\u015fa\u011f\u0131daki kan testlerini yapt\u0131rman\u0131z istenecektir. Bu testlerin, tedavi s\u0131ras\u0131ndaki durumunuzu g\u00f6stermesi beklendi\u011finden, tedaviden en ge\u00e7 2 hafta \u00f6nce yap\u0131lm\u0131\u015f olmas\u0131 gerekmektedir. Bu testler tedaviye ba\u015flarken ve her tedavi k\u00fcr\u00fcnden \u00f6nce yap\u0131lacakt\u0131r.<\/p>\r\n<ul>\r\n<li>PSA<\/li>\r\n<li>Tam kan say\u0131m\u0131<\/li>\r\n<li>Alkalen fosfataz<\/li>\r\n<\/ul>\r\n<p>Hekiminiz, gerekti\u011finde ek kan testleri de isteyebilir. Karaci\u011fer ve b\u00f6brek yetmezli\u011fi olan hastalar\u0131m\u0131zda, Radyum-223 tedavisi herhangi bir doz ayarlamas\u0131na gitmeden uygulanabilir.Kemik k\u0131r\u0131\u011f\u0131 ya da omurilik bas\u0131s\u0131 olan hastalar\u0131m\u0131zda ise \u00f6ncelikle bu sorunlar\u0131n d\u00fczeltilmesi istenecektir.<\/p>\r\n<p>Kemoterapi tedavisi ald\u0131ysan\u0131z en son k\u00fcr\u00fcn \u00fczerinden en az 4 hafta ge\u00e7ti\u011finden emin olman\u0131z gerekmektedir.Tedavi s\u0131ras\u0131nda evden getirdi\u011finiz kendi giysilerinizi giyece\u011finiz i\u00e7in rahat ve geni\u015f k\u0131yafetler tercih etmenizi \u00f6neririz. Tedaviniz ve birlikte yap\u0131lan testler i\u00e7in kolunuza veya elinizin s\u0131rt\u0131na yerle\u015ftirilen damar yolu kullan\u0131laca\u011f\u0131ndan, k\u0131sa kollu ya da geni\u015f kollu giysileri bulundurman\u0131z yararl\u0131 olacakt\u0131r.<\/p>\r\n<p>Radyum-223 ba\u011f\u0131rsaktan at\u0131ld\u0131\u011f\u0131 i\u00e7in \u201c\u00fclseratif kolit\u201d ve \u201cCrohn hastal\u0131\u011f\u0131\u201d gibi enflamatuar ba\u011f\u0131rsak hastal\u0131\u011f\u0131 olan ya da ba\u011f\u0131rsak t\u0131kan\u0131kl\u0131\u011f\u0131 hikayesi bulunan hastalar\u0131m\u0131zda ek destekleyici \u00f6nlemler almam\u0131z gerekebilir.<\/p>\r\n<h3>Radyum-223 Tedavisi Nas\u0131l Uygulan\u0131r?<\/h3>\r\n<p>Standard Radyum-223 tedavisi; d\u00f6rt haftal\u0131k aral\u0131klarla, toplam alt\u0131 tedavi k\u00fcr\u00fcnden (6 adet, birer dakikal\u0131k enjeksiyon) olu\u015fmaktad\u0131r. Sizin i\u00e7in \u00fcretilmi\u015f, kullan\u0131ma haz\u0131r Radyum-223 diklor\u00fcr \u00e7\u00f6zeltisi, N\u00fckleer T\u0131p Klini\u011finde, yerle\u015ftirdi\u011fimiz periferik damar yoluyla enjekte edilecektir.<\/p>\r\n<p>Radyum-223 uygulamadan \u00f6nce, damar yolunuzun a\u00e7\u0131kl\u0131\u011f\u0131, en az 10 ml serum fizyolojik ile y\u0131kanarak kontrol edilecek ve Radyum-223 yakla\u015f\u0131k 1 dakika boyunca yava\u015f enjeksiyon \u015feklinde uygulanacak, sonras\u0131nda damar yolunuz yine en az 10 ml serum fizyolojik ile y\u0131kanacakt\u0131r. Bu i\u015flem s\u0131ras\u0131nda a\u011fr\u0131 hissedilmemektedir.<\/p>\r\n<p>Enjeksiyondan sonra Radyum-223 diklor\u00fcr h\u0131zla kandan temizlenecek ve \u00f6ncelikle kemik ve kemik metastazlar\u0131nda tutulacak veya ba\u011f\u0131rsa\u011fa at\u0131lacakt\u0131r.<\/p>\r\n<h3>Olas\u0131 Yan Etkiler ve Talimatlar<\/h3>\r\n<p>Radyum-223 tedavisi uygulanan hastalar\u0131m\u0131zda g\u00f6r\u00fclebilecek en yayg\u0131n yan etkiler (\u2265% 10) bulant\u0131, kusma ve ishaldir. Ayr\u0131ca kan h\u00fccre say\u0131s\u0131nda ge\u00e7ici d\u00fc\u015fmeler g\u00f6r\u00fclebilmektedir.<\/p>\r\n<p><strong>Tedavi alan hastalar\u0131m\u0131z\u0131n a\u015fa\u011f\u0131daki talimatlara uymalar\u0131 \u00f6nemlidir:<\/strong><\/p>\r\n<ul>\r\n<li style=\"list-style-type: none\">\r\n<ul>\r\n<li>Size belirtilen tarihlerde kan say\u0131m\u0131n\u0131z\u0131 yapt\u0131r\u0131n\u0131z. Kanama veya enfeksiyon belirtilerini hekiminize iletiniz.<\/li>\r\n<li>A\u011f\u0131zdan su al\u0131m\u0131n\u0131z iyi d\u00fczeyde olmal\u0131d\u0131r, v\u00fccut su d\u00fczeyi ve idrar \u00e7\u0131k\u0131\u015f\u0131n\u0131z\u0131 takip ediniz.<\/li>\r\n<li>V\u00fccudunuzun susuz kalmas\u0131 veya b\u00f6brek yetmezli\u011fi belirtileri geli\u015firse hekiminize bildiriniz.<\/li>\r\n<li>Tedavi sonras\u0131 di\u011fer insanlarla temas konusunda herhangi bir k\u0131s\u0131tlaman\u0131z yoktur.<\/li>\r\n<li>Radyum-223 al\u0131rken ve son enjeksiyondan sonra en az 1 hafta boyunca iyi hijyen uygulamalar\u0131na dikkat ediniz.<\/li>\r\n<\/ul>\r\n<\/li>\r\n<\/ul>\r\n<p>\u2013 Klozeti oturarak kullan\u0131n\u0131z ve her kullan\u0131mdan sonra sifonu en az 2 kez \u00e7ekiniz.<br \/>\u2013 \u0130drar ve d\u0131\u015fk\u0131 ile kirlenmi\u015f giysilerinizi derhal ve di\u011fer k\u0131yafetlerden ayr\u0131 olarak y\u0131kay\u0131n\u0131z.<\/p>\r\n<ul>\r\n<li>Bak\u0131c\u0131lar\u0131n\u0131z, bula\u015f\u0131 \u00f6nlemek i\u00e7in v\u00fccut s\u0131v\u0131lar\u0131n\u0131z\u0131 tutarken eldiven kullanmal\u0131, sonras\u0131nda ellerini y\u0131kamal\u0131d\u0131r.<\/li>\r\n<\/ul>\r\n<p>Cinsel olarak aktif olan hastalar\u0131m\u0131z prezervatif kullanmal\u0131 ve \u00fcreme potansiyeli olan kad\u0131n partnerleri de tedavi s\u0131ras\u0131nda ve tedavinin tamamlanmas\u0131n\u0131 takip eden 6 ay boyunca etkili bir do\u011fum kontrol y\u00f6ntemi uygulamal\u0131d\u0131r.<\/p>\r\n<p><a href=\"https:\/\/www.intheranostics.com\/iletisim\/\"><strong>Daha fazla bilgi i\u00e7in l\u00fctfen bizimle irtibata ge\u00e7iniz.<\/strong><\/a><\/p>[\/et_pb_text][et_pb_accordion disabled_on=\"on|on|on\" _builder_version=\"%224.4.8%22\" disabled=\"on\"][et_pb_accordion_item title=\"%22TANI\" open=\"on\" open_toggle_text_color=\"%22#0ca7c5%22\" _builder_version=\"%224.4.8%22\" toggle_font=\"%22|700|||||||%22\" toggle_font_size=\"%2218px%22\"]<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT Nedir, T\u00fcm\u00f6r Oda\u011f\u0131n\u0131 Nas\u0131l G\u00f6sterir?<\/b><\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b><span style=\"float: none;background-color: #ffffff;color: #666666;font-family: 'Quicksand',Helvetica,Arial,Lucida,sans-serif;font-size: 100%;font-style: normal;font-variant: normal;font-weight: 500;letter-spacing: normal;text-align: left;text-decoration: none;text-indent: 0px;text-transform: none\">Teranostik t\u0131p d\u00fcnyas\u0131nda yeni geli\u015fmekte olan bir aland\u0131r. T\u00fcm\u00f6re \u00f6zg\u00fcl bir ila\u00e7 ile g\u00f6r\u00fcnt\u00fcleme yaparak saptanan t\u00fcm\u00f6r ve metastazlar\u0131n\u0131n, nereye gidece\u011fi, ne kadar gidece\u011fi ve hastal\u0131kl\u0131 dokuyu etkileme g\u00fcc\u00fc \u00f6nceden bilinen yine \u00f6zg\u00fcl bir ila\u00e7 ile tedavi edilebildi\u011fi bir yakla\u015f\u0131md\u0131r. Bu yakla\u015f\u0131m, geleneksel t\u0131ptan ki\u015fiye \u00f6zg\u00fc \u00e7a\u011fda\u015f t\u0131p uygulamalar\u0131na ge\u00e7i\u015f yap\u0131lmas\u0131n\u0131 sa\u011flamaktad\u0131r.<\/span><\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Prostat kanserinden \u00f6l\u00fcmler genellikle kemik metastaz\u0131 ve komplikasyonlar\u0131ndan kaynaklanmaktad\u0131r. Prostat kanseri kemik metastazlar\u0131\u00a0Flor-18 NaF (<\/span><span class=\"s2\"><sup>18<\/sup><\/span><span class=\"s1\">F-NaF) PET\/BT ile y\u00fcksek duyarl\u0131l\u0131kla g\u00f6r\u00fcnt\u00fclenebilmekte ve Radyum-223 ile bu t\u00fcm\u00f6ral dokular\u0131n \u00f6zg\u00fcl ve hedefe y\u00f6nelik tedavisi yap\u0131labilmektedir. Bu, teranostik uygulamalar i\u00e7in olduk\u00e7a ba\u015far\u0131l\u0131 bir \u00f6rnektir.<\/span><\/p>\r\n<p class=\"p4\"><span class=\"s1\">Hastal\u0131\u011f\u0131n\u0131z\u0131 takip eden hekiminiz, kemik metastazlar\u0131n\u0131n tan\u0131s\u0131 amac\u0131yla size bu tetkiki \u00f6nerebilir.\u00a0F-18 NaF PET\/BT; kemik metastazlar\u0131n\u0131n yeri ve yayg\u0131nl\u0131\u011f\u0131n\u0131 do\u011fru bir \u015fekilde g\u00f6sterirken a\u011fr\u0131l\u0131 kemik metastazlar\u0131nda hedefe y\u00f6nelik ba\u015far\u0131l\u0131 bir tedavi se\u00e7ene\u011fi olan Radyum-223 tedavisinin kullan\u0131m\u0131n\u0131 da m\u00fcmk\u00fcn k\u0131lar.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT\u2019nin \u00dcst\u00fcn Yanlar\u0131 Nelerdir?<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">F-18 NaF PET\/BT, kemik g\u00f6r\u00fcnt\u00fcleme maddesi olarak ideal \u00f6zelliklere sahiptir ve 45-60 dakika gibi k\u0131sa bir s\u00fcre i\u00e7inde \u00fcst\u00fcn kalitede g\u00f6r\u00fcnt\u00fcler \u00fcretir.\u00a0Ba\u015fta kemik metastaz\u0131 ara\u015ft\u0131r\u0131lan hastalar olmak \u00fczere bir\u00e7ok hasta i\u00e7in,\u00a0F-18 NaF PET\/BT, geleneksel kemik sintigrafisine g\u00f6re \u00e7ok daha ba\u015far\u0131l\u0131 sonu\u00e7lar\u0131 ile ideal bir alternatiftir.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT Kimlere Uygulan\u0131r?<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Hastal\u0131\u011f\u0131n\u0131z\u0131 takip eden hekiminiz sizden\u00a0F-18 NaF PET\/BT taramas\u0131n\u0131 \u015fu ama\u00e7lar i\u00e7in isteyebilir:<\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"p4\"><span class=\"s1\">Kemik metastazlar\u0131n\u0131n belirlenmesi<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">Hastal\u0131\u011f\u0131n yayg\u0131nl\u0131\u011f\u0131n\u0131n do\u011fru belirlenmesi<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">Malign kemik lezyonlar\u0131n\u0131n yerinin belirlenmesi<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">Kemik a\u011fr\u0131lar\u0131n\u0131n sa\u011falt\u0131m\u0131 i\u00e7in Radyum-223 tedavisinin uygun olup olmad\u0131\u011f\u0131n\u0131n belirlenmesi<\/span><\/li>\r\n \t<li class=\"p4\">Tedavi yan\u0131t\u0131n\u0131n de\u011ferlendirilmesi<\/li>\r\n<\/ul>\r\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT G\u00fcvenli midir?<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">F-18 NaF bilinen yan etkisi olmayan g\u00fcvenli bir radyoaktif maddedir. Bu i\u015flemde al\u0131nan radyasyon dozu azd\u0131r ve g\u00fcn sonunda v\u00fccudunuzdan temizlenir. N\u00fckleer T\u0131p klini\u011finden ayr\u0131lman\u0131z birka\u00e7 saat s\u00fcrmektedir. PET\/BT taramas\u0131n\u0131 izleyen 6 saat boyunca ba\u015fkalar\u0131yla (\u00f6zellikle \u00e7ocuklar ve hamile kad\u0131nlar) temas\u0131n\u0131z\u0131 en aza indirmenizi \u00f6nermekteyiz.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT \u00d6ncesi Haz\u0131rl\u0131k<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">F-18 NaF PET\/BT g\u00f6r\u00fcnt\u00fclemesi \u00f6ncesinde N\u00fckleer T\u0131p b\u00f6l\u00fcm\u00fcne iletmek \u00fczere, hastal\u0131\u011f\u0131n\u0131za y\u00f6nelik baz\u0131 tetkik ve bilgileri yan\u0131n\u0131zda bulundurman\u0131z istenecektir:<\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"p4\"><span class=\"s1\">Hekim istem formu<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">Prostat kanseri hikayeniz (\u00f6rn. PSA, patoloji sonu\u00e7lar\u0131)<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">\u00d6nceki onkolojik tedavilerinizin tipi ve tarihi (\u00f6rn. kemoterapi ve\/veya radyoterapi)<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">\u00d6nceki k\u0131r\u0131klar\u0131n\u0131z veya yak\u0131n tarihli travma hikayeniz (yeri ve tarihi)<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">\u00d6nceki ortopedik cerrahi giri\u015fimleriniz (m\u00fcdahale tarihi, tipi ve yeri)<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">\u00d6nceki enfeksiyon ve yeri<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">\u0130drar yolu ile ilgili ge\u00e7irilmi\u015f ameliyatlar<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">Her bir kemik a\u011fr\u0131n\u0131z\u0131n yeri<\/span><\/li>\r\n \t<li class=\"p4\"><span class=\"s1\">Di\u011fer g\u00f6r\u00fcnt\u00fclemeler ve raporlar\u0131 (\u00f6zellikle kemik sintigrafisi, BT veya MRI)<\/span><\/li>\r\n<\/ul>\r\n<p class=\"p2\"><span class=\"s1\">F-18 NaF PET\/BT i\u015flemi i\u00e7in a\u00e7 olman\u0131za gerek yoktur. \u0130la\u00e7lar\u0131n\u0131z\u0131 her zamanki gibi alabilirsiniz. <\/span><span class=\"s1\">B\u00f6brekten at\u0131l\u0131m\u0131 art\u0131rmak, al\u0131nan radyasyon dozunu azaltmak ve en iyi g\u00f6r\u00fcnt\u00fc kalitesine ula\u015fmak i\u00e7in,\u00a0F-18 NaF enjeksiyonu \u00f6ncesinde ve sonras\u0131nda en az iki\u015fer bardak su i\u00e7melisiniz. Tetkik sonras\u0131nda g\u00fcn\u00fcn geri kalan\u0131nda da su i\u00e7meye devam etmeniz faydal\u0131 olacakt\u0131r.\u00a0\u0130\u015flem s\u0131ras\u0131nda g\u00f6r\u00fcnt\u00fc bozulmalar\u0131n\u0131 \u00f6nlemek i\u00e7in t\u00fcm metal e\u015fyalar\/tak\u0131lar\/protezler \u00e7\u0131kar\u0131lmal\u0131d\u0131r.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Flor-18 NaF PET\/BT Nas\u0131l Uygulan\u0131r?<\/b><\/span><\/p>\r\n<p class=\"p4\"><span class=\"s1\">Az miktarda (1.5-3.7 Mbq\/Kg (0.04-0.1 mCi\/Kg) dozunda) F-18-NaF, g\u00f6r\u00fcnt\u00fcleme i\u015fleminden yakla\u015f\u0131k 30-60 dakika \u00f6nce, kol ya da el s\u0131rt\u0131n\u0131za yerle\u015ftirdi\u011fimiz damar yolundan uygulanacakt\u0131r.\u00a0<\/span><span class=\"s1\">F-18 NaF PET\/BT g\u00f6r\u00fcnt\u00fclemesinden hemen \u00f6nce mesanenizi bo\u015faltman\u0131z gerekmektedir.<\/span><\/p>\r\n<p class=\"p4\"><span class=\"s1\">PET\/BT g\u00f6r\u00fcnt\u00fclemesi boyunca (yakla\u015f\u0131k 20-25 dk.), v\u00fccut g\u00f6r\u00fcnt\u00fclerinin s\u00fcrekli kaydedildi\u011fi, her iki ucu a\u00e7\u0131k, geni\u015f halka \u015feklindeki bir cihazda, \u00f6zel \u00e7ekim yata\u011f\u0131 \u00fczerinde uzanman\u0131z istenecektir. \u0130\u015flemin tek zahmetli yan\u0131; bu s\u00fcre zarf\u0131nda hareketsiz kalman\u0131zd\u0131r. \u0130htiyac\u0131n\u0131z halinde, g\u00f6r\u00fcnt\u00fcleme \u00f6ncesi, beraberinizde getirdi\u011finiz a\u011fr\u0131 kesicinizi kullanabilirsiniz.<\/span><\/p>\r\n<p class=\"p4\"><span class=\"s1\">\u0130htiya\u00e7 duyulursa uzmanlar\u0131m\u0131z ek g\u00f6r\u00fcnt\u00fc alabilir. Ek g\u00f6r\u00fcnt\u00fcleme i\u015flemi yakla\u015f\u0131k 10-15 dakika s\u00fcrmektedir. <\/span><span class=\"s1\">N\u00fckleer T\u0131p klini\u011findeki i\u015flemlerin tamamlanmas\u0131 birka\u00e7 saati bulabilir. <\/span><span class=\"s1\">Kolunuzdaki damar yolu, g\u00f6r\u00fcnt\u00fclemeniz tamamland\u0131ktan ve t\u00fcm g\u00f6r\u00fcnt\u00fcleriniz kontrol edildikten sonra \u00e7\u0131kart\u0131lacakt\u0131r. Sa\u011fl\u0131k personelimizin onay vermesiyle, N\u00fckleer T\u0131p b\u00f6l\u00fcm\u00fcnden art\u0131k g\u00fcvenle ayr\u0131labilirsiniz.<\/span><\/p>\r\n<p class=\"p4\"><span class=\"s1\">\u0130la\u00e7 verildikten sonra ilk 6 saat k\u00fc\u00e7\u00fck \u00e7ocuklarla ve hamile kad\u0131nlarla temastan ka\u00e7\u0131nman\u0131z gerekti\u011fini l\u00fctfen unutmay\u0131n\u0131z. G\u00f6r\u00fcnt\u00fcleriniz N\u00fckleer T\u0131p Uzmanlar\u0131m\u0131z taraf\u0131ndan belirtilen s\u00fcrede de\u011ferlendirilerek rapor edilecektir.<\/span><\/p>\r\n[\/et_pb_accordion_item][et_pb_accordion_item title=\"TEDAV\u0130 H\u0130ZMETLER\u0130 - RADYUM-223 TEDAV\u0130S\u0130\" open_toggle_text_color=\"#0ca7c5\" _builder_version=\"4.4.8\" toggle_font=\"|700|||||||\" toggle_font_size=\"18px\" open=\"off\"]<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi Nedir?<\/b><\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\">Teranostik t\u0131p d\u00fcnyas\u0131nda yeni geli\u015fmekte olan bir aland\u0131r. T\u00fcm\u00f6re \u00f6zg\u00fcl bir ila\u00e7 ile g\u00f6r\u00fcnt\u00fcleme yaparak saptanan t\u00fcm\u00f6r ve metastazlar\u0131n\u0131n, nereye gidece\u011fi-ne kadar gidece\u011fi ve hastal\u0131kl\u0131 dokuyu etkileme g\u00fcc\u00fc \u00f6nceden bilinen yine \u00f6zg\u00fcl bir ila\u00e7 ile tedavi edilebildi\u011fi bir yakla\u015f\u0131md\u0131r. Bu yakla\u015f\u0131m, geleneksel t\u0131ptan ki\u015fiye \u00f6zg\u00fc \u00e7a\u011fda\u015f t\u0131p uygulamalar\u0131na ge\u00e7i\u015f yap\u0131lmas\u0131n\u0131 sa\u011flamaktad\u0131r.<\/span><\/p>\r\n<p class=\"p2\">Prostat kanseri<strong>\u00a0<\/strong>v\u00fccudun di\u011fer b\u00f6lgelerine yay\u0131ld\u0131\u011f\u0131nda, s\u0131kl\u0131kla kemiklerde yerle\u015fmektedir. Kemik metastaz\u0131 a\u011fr\u0131 d\u0131\u015f\u0131nda, k\u0131r\u0131k, omurilik s\u0131k\u0131\u015fmas\u0131 veya hayat\u0131 tehdit edebilen y\u00fcksek kan kalsiyum seviyeleri gibi ba\u015fka sorunlara da neden olabilir. Kanser kemiklere ula\u015ft\u0131\u011f\u0131nda, a\u011fr\u0131y\u0131 ve di\u011fer komplikasyonlar\u0131 kontrol etmek veya hafifletmek tedavinin \u00e7ok \u00f6nemli bir par\u00e7as\u0131d\u0131r. Hormon tedavisi, kemoterapi ve a\u015f\u0131lar gibi tedaviler buna yard\u0131mc\u0131 olabilir. Ancak uygun hastalarda, \u00f6zellikle kemik metastaz\u0131n\u0131 hedef alan ve alfa \u0131\u015f\u0131mas\u0131 yapan Radyum-223 tedavisi ile bir yandan semptomlar kontrol alt\u0131na al\u0131n\u0131rken bir yandan da sa\u011f kal\u0131m\u0131 art\u0131r\u0131c\u0131 etki sa\u011flanabilmektedir.<\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Nas\u0131l Tedavi Eder?<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Radyum-223, kemik metastazlar\u0131na se\u00e7ici olarak ba\u011flanan ve \u00e7ok k\u0131sa menzilli y\u00fcksek enerjili par\u00e7ac\u0131klar\u0131 (<100 \u03bcm) yayan, radyoaktif bir elementtir. Radyum-223 diklor\u00fcr molek\u00fcl\u00fc, kalsiyumu taklit ederek kemik metastazlar\u0131na ba\u011flan\u0131r ve ard\u0131ndan y\u00fcksek enerjili alfa par\u00e7ac\u0131\u011f\u0131na ait radyasyon, DNA k\u0131r\u0131klar\u0131na neden olarak t\u00fcm\u00f6r h\u00fccrelerini \u00f6ld\u00fcr\u00fcr. Alfa par\u00e7ac\u0131klar\u0131n\u0131n k\u0131sa olan menzili, kom\u015fu sa\u011fl\u0131kl\u0131 doku ve \u00f6zellikle kemik ili\u011fi \u00fczerindeki zararl\u0131 etkinin de en az d\u00fczeyde kalmas\u0131 anlam\u0131na gelmektedir.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Sa\u011f kal\u0131m\u0131 uzatt\u0131\u011f\u0131 bilinen kemi\u011fe \u00f6zg\u00fc tek ila\u00e7, radyoaktif alfa par\u00e7ac\u0131\u011f\u0131 yayarak tedavi edici etkisini g\u00f6steren Radyum-223't\u00fcr. Bilimsel \u00e7al\u0131\u015fmalar ile Radyum-223 tedavisinin ortalama ya\u015fam s\u00fcresini uzatt\u0131\u011f\u0131 g\u00f6sterilmi\u015ftir. Buna ek olarak a\u011fr\u0131da ve ya\u015fam kalitesinde iyile\u015fmeyi sa\u011flamaktad\u0131r. T\u00fcm bu faydalar\u0131n\u0131n yan\u0131nda kan de\u011ferlerinde ge\u00e7ici d\u00fc\u015fme ve ishal d\u0131\u015f\u0131nda Radyum-223 tedavisi ile ili\u015fkili yan etkiler olduk\u00e7a hafif d\u00fczeylerde izlenmi\u015ftir.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi Kimlere Uygulan\u0131r?<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisi \u00e7ok spesifik bir tedavi t\u00fcr\u00fcd\u00fcr, bu nedenle sadece kemiklere yay\u0131lm\u0131\u015f ve a\u011fr\u0131 \u015fikayeti olan prostat kanserli hastalarda, takip eden hekimleri taraf\u0131ndan uygun g\u00f6r\u00fclmesi durumunda uygulanabilir.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisi, kemi\u011fe yay\u0131lm\u0131\u015f kanserin s\u0131kl\u0131kla neden oldu\u011fu a\u011fr\u0131y\u0131 hafifletebilir. Bu tedavinin uygulanmas\u0131na karar verildi\u011finde, tedavi \u00f6ncesinde, t\u00fcm v\u00fccut kemik taramas\u0131 (\u00f6rn. F-NaF PET\/BT, kemik sintigrafisi) yap\u0131lmaktad\u0131r. Bu, Radyum-223'\u00fcn tedavi s\u0131ras\u0131nda do\u011fru alanlar\u0131 hedefledi\u011finden emin olunmas\u0131n\u0131 sa\u011flayacakt\u0131r.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi G\u00fcvenli midir?<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisinde kullan\u0131lan alfa radyasyonu \u00e7ok y\u00fcksek bir enerji seviyesine sahiptir. Bununla birlikte alfa radyasyon, do\u011fas\u0131 gere\u011fi sadece \u00e7ok k\u0131sa mesafelere (iki ila on h\u00fccre mesafesinde) seyahat eder ve bu da radyasyonun yok edici etkisinin sa\u011fl\u0131kl\u0131 h\u00fccrelerde de\u011fil, kemikteki kanser h\u00fccrelerinde olu\u015fmas\u0131n\u0131 sa\u011flamaktad\u0131r. Sa\u011fl\u0131kl\u0131 h\u00fccrelerce al\u0131nan minimal radyasyon dozu, Radium-223 tedavisi ile ili\u015fkili yan etkilerin de ihmal edilebilir d\u00fczeyde oldu\u011fu anlam\u0131na gelir ve \u00fcretilen kan h\u00fccrelerinin say\u0131s\u0131nda ge\u00e7ici bir azalma ve nadiren bulant\u0131, kusma ve ishal, tedavi olan hastalar\u0131m\u0131zda g\u00f6r\u00fclebilmektedir.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi \u00d6ncesi Haz\u0131rl\u0131k \u00a0<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Klini\u011fe ilk ba\u015fvurunuzda, a\u015fa\u011f\u0131da listelenen bilgi ve belgeleri beraberinizde getirmeniz \u00f6nemlidir. Hasta bilgilerinizin dijital ortamda haz\u0131rlanmas\u0131 (DICOM, JPEG, PNG, PDF, Microsoft Word (.doc, .docx, vb.)), e-posta ile h\u0131zl\u0131 ve kolayca payla\u015f\u0131lmas\u0131na imkan tan\u0131yacak ve hastal\u0131\u011f\u0131n\u0131z\u0131n de\u011ferlendirilmesini b\u00fcy\u00fck oranda kolayla\u015ft\u0131racakt\u0131r:<\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"p2\"><span class=\"s1\">Sizin ve sizi takip eden hekiminizin ileti\u015fim bilgileri (ev\/i\u015f\/cep telefon numaras\u0131, e-posta adresi)<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">En g\u00fcncel hekim raporlar\u0131<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Patoloji raporlar\u0131<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Kan testleri<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">T\u00fcm v\u00fccut kemik sintigrafisi, BT, MR ve 68Ga-PSMA PET\/BT, 18F-FDG PET\/BT raporlar\u0131 ve orijinal film\/CD\/DVD'leri<\/span><\/li>\r\n<\/ul>\r\n<p class=\"p2\"><span class=\"s1\">N\u00fckleer T\u0131p Hekiminiz, bu tedavi \u00f6ncesinde ihtiya\u00e7 duyulmas\u0131 halinde, tedaviye uygunlu\u011funuzu de\u011ferlendirmek amac\u0131yla 18F-NaF PET\/BT veya t\u00fcm v\u00fccut kemik sintigrafisi g\u00f6r\u00fcnt\u00fclemeleri ile kemik erimesi varl\u0131\u011f\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 i\u00e7in kemik mineral yo\u011funlu\u011fu \u00f6l\u00e7\u00fcm\u00fc isteyebilir.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Ayr\u0131ca a\u015fa\u011f\u0131daki kan testlerini yapt\u0131rman\u0131z istenecektir. Bu testlerin, tedavi s\u0131ras\u0131ndaki durumunuzu g\u00f6stermesi beklendi\u011finden, tedaviden en ge\u00e7 2 hafta \u00f6nce yap\u0131lm\u0131\u015f olmas\u0131 gerekmektedir. Bu testler tedaviye ba\u015flarken ve her tedavi k\u00fcr\u00fcnden \u00f6nce yap\u0131lacakt\u0131r.<\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"p2\"><span class=\"s1\">PSA<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Tam kan say\u0131m\u0131<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Alkalen fosfataz<\/span><\/li>\r\n<\/ul>\r\n<p class=\"p2\"><span class=\"s1\">Hekiminiz, gerekti\u011finde ek kan testleri de isteyebilir. <\/span><span class=\"s1\">Karaci\u011fer ve b\u00f6brek yetmezli\u011fi olan hastalar\u0131m\u0131zda, Radyum-223 tedavisi herhangi bir doz ayarlamas\u0131na gitmeden uygulanabilir.<\/span><span class=\"s1\">Kemik k\u0131r\u0131\u011f\u0131 ya da omurilik bas\u0131s\u0131 olan hastalar\u0131m\u0131zda ise \u00f6ncelikle bu sorunlar\u0131n d\u00fczeltilmesi istenecektir.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Kemoterapi tedavisi ald\u0131ysan\u0131z en son k\u00fcr\u00fcn \u00fczerinden en az 4 hafta ge\u00e7ti\u011finden emin olman\u0131z gerekmektedir.<\/span><span class=\"s1\">Tedavi s\u0131ras\u0131nda evden getirdi\u011finiz kendi giysilerinizi giyece\u011finiz i\u00e7in rahat ve geni\u015f k\u0131yafetler tercih etmenizi \u00f6neririz. Tedaviniz ve birlikte yap\u0131lan testler i\u00e7in kolunuza veya elinizin s\u0131rt\u0131na yerle\u015ftirilen damar yolu kullan\u0131laca\u011f\u0131ndan, k\u0131sa kollu ya da geni\u015f kollu giysileri bulundurman\u0131z yararl\u0131 olacakt\u0131r.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Radyum-223 ba\u011f\u0131rsaktan at\u0131ld\u0131\u011f\u0131 i\u00e7in \u201c\u00fclseratif kolit\u201d ve \u201cCrohn hastal\u0131\u011f\u0131\u201d gibi enflamatuar ba\u011f\u0131rsak hastal\u0131\u011f\u0131 olan ya da ba\u011f\u0131rsak t\u0131kan\u0131kl\u0131\u011f\u0131 hikayesi bulunan hastalar\u0131m\u0131zda ek destekleyici \u00f6nlemler almam\u0131z gerekebilir.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Radyum-223 Tedavisi Nas\u0131l Uygulan\u0131r?<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Standard Radyum-223 tedavisi; d\u00f6rt haftal\u0131k aral\u0131klarla, toplam alt\u0131 tedavi k\u00fcr\u00fcnden (6 adet, birer dakikal\u0131k enjeksiyon) olu\u015fmaktad\u0131r. <\/span><span class=\"s1\">Sizin i\u00e7in \u00fcretilmi\u015f, kullan\u0131ma haz\u0131r Radyum-223 diklor\u00fcr \u00e7\u00f6zeltisi, N\u00fckleer T\u0131p Klini\u011finde, yerle\u015ftirdi\u011fimiz periferik damar yoluyla enjekte edilecektir.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Radyum-223 uygulamadan \u00f6nce, damar yolunuzun a\u00e7\u0131kl\u0131\u011f\u0131, en az 10 ml serum fizyolojik ile y\u0131kanarak kontrol edilecek ve Radyum-223 yakla\u015f\u0131k 1 dakika boyunca yava\u015f enjeksiyon \u015feklinde uygulanacak, sonras\u0131nda damar yolunuz yine en az 10 ml serum fizyolojik ile y\u0131kanacakt\u0131r. Bu i\u015flem s\u0131ras\u0131nda a\u011fr\u0131 hissedilmemektedir.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Enjeksiyondan sonra Radyum-223 diklor\u00fcr h\u0131zla kandan temizlenecek ve \u00f6ncelikle kemik ve kemik metastazlar\u0131nda tutulacak veya ba\u011f\u0131rsa\u011fa at\u0131lacakt\u0131r.<\/span><\/p>\r\n<p class=\"p1\"><span class=\"s1\"><b>Olas\u0131 Yan Etkiler ve Talimatlar<\/b><\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Radyum-223 tedavisi uygulanan hastalar\u0131m\u0131zda g\u00f6r\u00fclebilecek en yayg\u0131n yan etkiler (\u2265% 10) bulant\u0131, kusma ve ishaldir. Ayr\u0131ca kan h\u00fccre say\u0131s\u0131nda ge\u00e7ici d\u00fc\u015fmeler g\u00f6r\u00fclebilmektedir.<\/span><\/p>\r\n<p class=\"p2\"><span class=\"s1\">Tedavi alan hastalar\u0131m\u0131z\u0131n a\u015fa\u011f\u0131daki talimatlara uymalar\u0131 \u00f6nemlidir:\u00a0\u00a0<\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"p2\"><span class=\"s1\">Size belirtilen tarihlerde kan say\u0131m\u0131n\u0131z\u0131 yapt\u0131r\u0131n\u0131z. Kanama veya enfeksiyon belirtilerini hekiminize iletiniz.<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">A\u011f\u0131zdan su al\u0131m\u0131n\u0131z iyi d\u00fczeyde olmal\u0131d\u0131r, v\u00fccut su d\u00fczeyi ve idrar \u00e7\u0131k\u0131\u015f\u0131n\u0131z\u0131 takip ediniz.<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">V\u00fccudunuzun susuz kalmas\u0131 veya b\u00f6brek yetmezli\u011fi belirtileri geli\u015firse hekiminize bildiriniz.<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Tedavi sonras\u0131 di\u011fer insanlarla temas konusunda herhangi bir k\u0131s\u0131tlaman\u0131z yoktur.<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Radyum-223 al\u0131rken ve son enjeksiyondan sonra en az 1 hafta boyunca iyi hijyen uygulamalar\u0131na dikkat ediniz.\r\n<\/span><span class=\"s1\">- Klozeti oturarak kullan\u0131n\u0131z ve her kullan\u0131mdan sonra sifonu en az 2 kez \u00e7ekiniz.\r\n<\/span><span class=\"s1\">- \u0130drar ve d\u0131\u015fk\u0131 ile kirlenmi\u015f giysilerinizi derhal ve di\u011fer k\u0131yafetlerden ayr\u0131 olarak y\u0131kay\u0131n\u0131z.<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Bak\u0131c\u0131lar\u0131n\u0131z, bula\u015f\u0131 \u00f6nlemek i\u00e7in v\u00fccut s\u0131v\u0131lar\u0131n\u0131z\u0131 tutarken eldiven kullanmal\u0131, sonras\u0131nda ellerini y\u0131kamal\u0131d\u0131r.<\/span><\/li>\r\n \t<li class=\"p2\"><span class=\"s1\">Cinsel olarak aktif olan hastalar\u0131m\u0131z prezervatif kullanmal\u0131 ve \u00fcreme potansiyeli olan kad\u0131n partnerleri de tedavi s\u0131ras\u0131nda ve tedavinin tamamlanmas\u0131n\u0131 takip eden 6 ay boyunca etkili bir do\u011fum kontrol y\u00f6ntemi uygulamal\u0131d\u0131r.<\/span><\/li>\r\n<\/ul>\r\n<p class=\"p2\"><span class=\"s1\"><i>Daha fazla bilgi i\u00e7in l\u00fctfen bizimle irtibata ge\u00e7iniz.<\/i><\/span><\/p>\r\n[\/et_pb_accordion_item][\/et_pb_accordion][et_pb_code _builder_version=\"4.4.8\"][\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section]","_et_gb_content_width":"","footnotes":""},"class_list":["post-2333","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Radium-223 Therapy - intheranostics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.intheranostics.com\/en\/radium-223-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Radium-223 Therapy - intheranostics\" \/>\n<meta property=\"og:description\" content=\"[et_pb_section fb_built=&#8221;1&#8243; 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